Barium chromate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Results of a guideline study are reported in summary only; however this study is referred to as the most reliable data available by the ICDA review and the EU RAR.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1985

Materials and methods

Principles of method if other than guideline:

Unclear; summary report only

GLP compliance:

not specified

Remarks:

Summary report only

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium chromate

EC Number:

231-889-5

EC Name:

Sodium chromate

Cas Number:

7775-11-3

Molecular formula:

CrH2O4.2Na

IUPAC Name:

disodium dioxido(dioxo)chromium

Constituent 2

Reference substance name:

Sodium dichromate

EC Number:

234-190-3

EC Name:

Sodium dichromate

Cas Number:

10588-01-9

Molecular formula:

Cr2Na2O7

IUPAC Name:

sodium dichromate

Constituent 3

Reference substance name:

Potassium dichromate

EC Number:

231-906-6

EC Name:

Potassium dichromate

Cas Number:

7778-50-9

Constituent 4

Reference substance name:

Ammonium dichromate

EC Number:

232-143-1

EC Name:

Ammonium dichromate

IUPAC Name:

ammonium dichromate

Details on test material:

No further details provided

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male/female

Details on test animals or test system and environmental conditions:

No further details: summary report only

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

Animals were gavaged with a single dose of the test materials dissolved in distilled water at a constant concentration of 5%

Doses:

No further details: summary report only

No. of animals per sex per dose:

No further details: summary report only

Control animals:

yes

Details on study design:

No further details: summary report only

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

51.1

Remarks on result:

other: sodium chromate

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

51.91

Remarks on result:

other: sodium dichromate

Effect levels 3

Sex:

male/female

Dose descriptor:

LD50

Effect level:

57.16

Remarks on result:

other: potassium dichromate

Any other information on results incl. tables

Numerous clinical observations were attributed to all four test compounds and were observed in both sexes. More prevalent observations included hypoactivity, lacrimation, mydriasis, diarrhoea, salivation and yellow anogenital staining. Reduced bodyweights were seen in surviving animals; necropsy did not reveal any treatment-related findings.

LD50 values were calculated to be as follows:

Compound	LD50 (mg/kg bw)
	M	F	M/F combined
Sodium chromate	67.08 ± 6.62	40.57 ± 12.38	51.91 ± 7.22
Sodium dichromate	56.64 ± 5.78	39.02 ± 13.54	51.10 ± 5.93
Potassium dichromate	74.11 ± 13.30	47.94 ± 6.49	57.16 ± 7.67

Applicant's summary and conclusion

Interpretation of results:

toxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The results of this study give LD50 values of between 25 and 200 mg/kg bw for each of the compounds investigated which would trigger classification as 'Toxic if swallowed' according to EU criteria.

Executive summary:

The acute oral toxicity of sodium chromate, sodium dichromate and potassium dichromate were investigated in F344 rats. All test compounds were found to be toxic, and produced a similar level of toxicity. LD50 values were calculated to be between 56.64 -74.11 mg/kg bw (males); 39.02 -47.94 mg/kg bw (females) and 51.10 -57.16 mg/kg bw for the sexes combined.

Although not reported in detail, the findings of this study are therefore consistent with those of the proprietary studies with the same compounds (Cuthbert & D'Arcy-Burt, 1983).