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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Long-Term Effects of 4-Aminopyridine Exposure to Birds and Fish
Author:
Schafer, E.W.Jr., and L.L. Marking
Year:
1975
Bibliographic source:
J. Wildl. Manag.39(4): 807-811 published on EPA Database ECOTOX Febraury 2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data published on a reliable Database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-pyridylamine
EC Number:
207-987-9
EC Name:
4-pyridylamine
Cas Number:
504-24-5
Molecular formula:
C5H6N2
IUPAC Name:
nickel
Test material form:
solid: particulate/powder

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Ictalurus punctatus

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Test conditions

Hardness:
hard water: 280-320 mg/L CaCO3
soft water: 40-48 mg/L CaCO3
Test temperature:
12 °C and 22°C
pH:
hard water: 7.2 - 7.6
soft water: 8 - 8.4
Dissolved oxygen:
not specified
Reference substance (positive control):
not specified

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
96 h
Dose descriptor:
LC50
Remarks:
hard water, 12°C
Effect conc.:
ca. 2.43 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Remarks:
soft water, 22°C
Effect conc.:
ca. 5.8 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Remarks:
soft water, 12°C
Effect conc.:
ca. 4 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Remarks:
soft water, 17°C
Effect conc.:
ca. 4.39 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
In the study different water hardnesses and temperatures were tested in a static sytem with the test organism Ictulurus Punctutus. LC50´s ranges from 2.43 mg/l in very hard water at 12 °C to 5.8 mg/l in soft water at 22 °C.
Executive summary:

In the study different water hardnesses and temperatures were tested in a static sytem with the test organism Ictulurus Punctutus. LC50´s ranges from 2.43 mg/l in very hard water at 12 °C to 5.8 mg/l in soft water at 22 °C.