2,2'-[(1-methylethylidene)bis(cyclohexane-4,1-diyloxymethylene)]bisoxirane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 April 2018 to 07 April 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

- The infrared (IR) spectrum of the test material measured at this laboratory was confirmed to be identical to that provided by the sponsor.
- In addition, the IR spectrum of the test material after the completion of the experiment was the same as that before the start of the experiment, and it indicated that the test material was stable under the storage conditions.

Key result

Water solubility:

63.1 mg/L

Conc. based on:

test mat.

Incubation duration:

4 d

Temp.:

20 °C

pH:

>= 6.2 - <= 6.7

Details on results:

- No adverse effects on the reliability of this test were noted.
- The maximum difference among the measurement results in sample 2, 3 and 4 was within 15%. Therefore, the water solubility was calculated from those results.
- Since the maximum difference of test material concentrations in the test solutions was within 15%, it is concluded that the test results are acceptable.

Table 1: Test Results

Agitation Period	Sample	pH	Concentration of Test Material in Test Solution (mg/L)			Maximum Difference (%)
			Measured Value	Average	Standard Deviation
1 day	1-a	6.3	43.8	-	-	34.9	-
	1-b	6.5	42.1
2 days	2-a	6.6	61.6	63.1	3.51		13.0
	2-b	6.6	64.6
3 days	3-a	6.2	59.2
	3-b	6.2	59.8
4 days	4-a	6.7	65.7			-
	4-b	6.7	68.0

Conclusions:

Under the conditions of this study the water solubility of the test material was 63.1 mg/L at 20°C.

Executive summary:

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions following the shake flask method.

During the study, eight test solutions were prepared and then agitated at 30°C with the shaking bath for either one, two, three or four days before pre-treatment and analysis using liquid chromatography-mass spectrometry.

The maximum difference among the measurement results in sample 2, 3 and 4 was within 15%. Therefore, the water solubility was calculated from those results. Since the maximum difference of test material concentrations in the test solutions was within 15%, it is concluded that the test results are acceptable.

Under the conditions of this study the water solubility of the test material was determined to be 63.1 mg/L at 20°C.

Description of key information

Under the conditions of the study the water solubility of the test material was determined to be 63.1 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:

63.1 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions following the shake flask method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

During the study, eight test solutions were prepared and then agitated at 30°C with the shaking bath for either one, two, three or four days before pre-treatment and analysis using liquid chromatography-mass spectrometry.

The maximum difference among the measurement results in sample 2, 3 and 4 was within 15%. Therefore, the water solubility was calculated from those results. Since the maximum difference of test material concentrations in the test solutions was within 15%, it is concluded that the test results are acceptable.

Under the conditions of this study the water solubility of the test material was determined to be 63.1 mg/L at 20°C.