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EC number: 221-518-5 | CAS number: 3130-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Introduction
No experimental data on absorption, distribution, metabolism and excretion are available for bis((3,4-epoxycyclohexyl)methyl) adipate (CAS Number 3130-19-6; EC Number 221-518-5) also known as Uvicure S128. Very limited toxicity data are available for Uvicure S128; the majority of the data come from the structurally similar substance 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate (CAS Number:2386-87-0;EC Number:219-207-4 – Source Substance). Toxicity data on the Source Substance in combination with the physicochemical data on Uvicure S128 were used to provide the toxicokinetic profile of Uvicure S128.
Physicochemical properties
The substanceUvicure S128is a clear viscous liquid with a molecular weight of 366.454 g/mol. The relative density of the test material was determined to be 1.1495 at 20°C. No melting point for the substance could be measuredin the temperature range from -100 to 250 °C. The vapour pressure ofUvicure S128 is 1.5 ×10-5, 2.8 ×10-5and 4.2 ×10-4Pa, at 20, 25 and 50 °C, respectively. Therefore,Uvicure S128is considered to be very low volatile substance and not available for inhalation as a vapour.
The partition coefficient logPow is 2.98 at 20 °C and the water solubility is < 2.0 mg/L at 20 °C. ThereforeUvicure S128is a moderately lipophilic substance which is poorly soluble in water. The substance is readily biodegradable in water.
Oral absorption
The relatively low MW and moderate Log Pow would appear to favour oral absorption, however, the low water solubility may limit the rate absorption from the gastrointestinal tract. Results from the acute oral study with Uvicure S128 show that part of the dose was still present in the stomach at necropsy of the animals which died during the study. Nevertheless, rats showed signs of toxicity after administration. The repeat-dose data in rats with the Source Substance identified systemic effects in nasal epithelium, as well as in the kidney and liver (target organs), indicating systemic exposure. Oral absorption does take place, but the exact extent cannot be determined, therefore, for risk assessment purposes the oral absorption of Uvicure S128 is considered 50% in accordance with ECHA guidance.
Dermal absorption
Although the Log Pow value of 2.98 can be considered optimal for dermal penetration into the stratum corneum, the poor water solubility suggests a low to moderate dermal absorption. The substance is not irritating to the skin. Classification for skin sensitisation is triggered for Uvicure S128 (Target Substance) based on data with the Source Substance. In the absence of any quantitative data and in line with the EC guidance on dermal absorption (EFSA Panel on Plant Protection Products and their Residues (PPR); Guidance on Dermal Absorption. EFSA Journal 2012;10(4):2665), the default value of 25% for dermal absorption will be used for human health risk assessment purposes.
Inhalation absorption
The low vapour pressure indicates that the substance cannot generate an inhalable vapour. Although the relatively low MW and moderate Log Pow would appear to favour absorption, the low water solubility suggest that most droplets, if inhaled, would not reach the alveolar region of the respiratory tract. However, in the absence of any quantitative data, and as a conservative approach, for human health risk assessment purposes absorption by inhalation is assumed to be 100%.
Distribution, Metabolism and Elimination
Repeat-dose oral toxicity studies with the Source Substance identified the liver, the kidney and the olfactory epithelium in the nasal tissues as the target organs. The relatively low molecular weight of the substance would suggest wider distribution although this might be countered by the low water solubility. There was however no evidence of bioaccumulation from the available repeat-dose toxicity studies.
Since positive results were obtained only in the presence of metabolic activation in in vitro genotoxicity tests with Uvicure S128 (Target Substance) and the Source Substance, it appears that Uvicure S128 is subjected to metabolism in the liver. The molecular weight would suggest prevalence of urinary excretion.
Conclusions
Oral, dermal and inhalation absorption of Uvicure S128 are considered to be 50%, 25% and 100%, respectively.
There is no potential for bioaccumulation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 25
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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