Registration Dossier
Registration Dossier
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EC number: 224-851-4 | CAS number: 4521-61-3
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
As a general rule, in case of doubt or if symptoms persist, always call a doctor.
NEVER induce swallowing by an unconscious person.
1. Description of first aid measures
In the event of exposure by inhalation :
In the event of massive inhalation of dust, remove the person exposed to fresh air. Keep warm and at rest.
If the person is unconscious, place in recovery position. Notify a doctor in all events, to ascertain whether observation and supportive hospital
care will be necessary.
If breathing is irregular or has stopped, effect mouth-to-mouth resuscitation and call a doctor.
Stop breathing in and out of the contaminated area.
In the event of splashes or contact with eyes :
Wash thoroughly with fresh, clean water for 15 minutes holding the eyelids open.
Regardless of the initial state, refer the patient to an ophthalmologist and show him the label.
If there is any redness, pain or visual impairment, consult an ophthalmologist.
In the event of splashes or contact with skin :
Remove any soiled or splashed clothing immediately.
Watch out for any remaining product between skin and clothing, watches, shoes, etc.
If the contaminated area is widespread and/or there is damage to the skin, a doctor must be consulted or the patient transferred to hospital.
In the event of swallowing :
Do not give the patient anything orally.
In the event of swallowing, if the quantity is small (no more than one mouthful), rinse the mouth with water, administer activated medical
charcoal and consult a doctor.
Seek medical attention immediately, showing the label.
If swallowed accidentally, call a doctor to ascertain whether observation and hospital care will be necessary. Show the label.
NEVER induce swallowing by an unconscious person.
1. Description of first aid measures
In the event of exposure by inhalation :
In the event of massive inhalation of dust, remove the person exposed to fresh air. Keep warm and at rest.
If the person is unconscious, place in recovery position. Notify a doctor in all events, to ascertain whether observation and supportive hospital
care will be necessary.
If breathing is irregular or has stopped, effect mouth-to-mouth resuscitation and call a doctor.
Stop breathing in and out of the contaminated area.
In the event of splashes or contact with eyes :
Wash thoroughly with fresh, clean water for 15 minutes holding the eyelids open.
Regardless of the initial state, refer the patient to an ophthalmologist and show him the label.
If there is any redness, pain or visual impairment, consult an ophthalmologist.
In the event of splashes or contact with skin :
Remove any soiled or splashed clothing immediately.
Watch out for any remaining product between skin and clothing, watches, shoes, etc.
If the contaminated area is widespread and/or there is damage to the skin, a doctor must be consulted or the patient transferred to hospital.
In the event of swallowing :
Do not give the patient anything orally.
In the event of swallowing, if the quantity is small (no more than one mouthful), rinse the mouth with water, administer activated medical
charcoal and consult a doctor.
Seek medical attention immediately, showing the label.
If swallowed accidentally, call a doctor to ascertain whether observation and hospital care will be necessary. Show the label.
Fire-fighting measures
Non-flammable.
1. Extinguishing media
In the event of fire, use specifically suitable extinguishing agents. Never use water.
Suitable methods of extinction
In the event of a fire, use :
All extinguishing except WATER
Unsuitable methods of extinction
In the event of a fire, do not use :
- water
2. Special hazards arising from the substance or mixture
A fire will often produce a thick black smoke. Exposure to decomposition products may be hazardous to health.
Do not breathe in smoke.
In the event of a fire, the following may be formed :
- carbon monoxide (CO)
- carbon dioxide (CO2)
- hydrogen chloride (HCl)
3. Advice for firefighters
Due to the toxicity of the gas emitted on thermal decomposition of the products, fire-fighting personnel are to be equipped with autonomous insulating
breathing apparatus.
1. Extinguishing media
In the event of fire, use specifically suitable extinguishing agents. Never use water.
Suitable methods of extinction
In the event of a fire, use :
All extinguishing except WATER
Unsuitable methods of extinction
In the event of a fire, do not use :
- water
2. Special hazards arising from the substance or mixture
A fire will often produce a thick black smoke. Exposure to decomposition products may be hazardous to health.
Do not breathe in smoke.
In the event of a fire, the following may be formed :
- carbon monoxide (CO)
- carbon dioxide (CO2)
- hydrogen chloride (HCl)
3. Advice for firefighters
Due to the toxicity of the gas emitted on thermal decomposition of the products, fire-fighting personnel are to be equipped with autonomous insulating
breathing apparatus.
Accidental release measures
.1. Personal precautions, protective equipment and emergency procedures
Consult the safety measures listed under sections "Handling and storage" and "Exposure controls/ Personal Protection".
For non first aid worker
Avoid any contact with the skin and eyes.
Avoid inhaling dust.
If a large quantity has been spilt, evacuate all personnel and only allow intervention by trained operators equipped with safety apparatus.
Evacuate personnel in the danger zone.
For first aid worker
First aid workers will be equipped with suitable personal protective equipment (See section 8).
2. Environmental precautions
Prevent any material from entering drains or waterways.
3. Methods and material for containment and cleaning up
Retrieve the product by mechanical means (sweeping/vacuuming)
Consult the safety measures listed under sections "Handling and storage" and "Exposure controls/ Personal Protection".
For non first aid worker
Avoid any contact with the skin and eyes.
Avoid inhaling dust.
If a large quantity has been spilt, evacuate all personnel and only allow intervention by trained operators equipped with safety apparatus.
Evacuate personnel in the danger zone.
For first aid worker
First aid workers will be equipped with suitable personal protective equipment (See section 8).
2. Environmental precautions
Prevent any material from entering drains or waterways.
3. Methods and material for containment and cleaning up
Retrieve the product by mechanical means (sweeping/vacuuming)
Handling and storage
Requirements relating to storage premises apply to all facilities where the substance is handled.
1. Precautions for safe handling
Always wash hands after handling.
Remove and wash contaminated clothing before re-using.
Provide emergency showers and eye wash stations will be required in facilities where the substance is handled constantly.
Fire prevention :
Handle in well-ventilated areas.
Prevent access by unauthorised personnel.
Recommended equipment and procedures :
For personal protection, see section "Exposure controls/ Personal protection".
Observe precautions stated on label and also industrial safety regulations.
Never bring water into contact with this substance.
Do not breathe in dust.
Also provide breathing apparatus for certain short tasks of an exceptional nature and for emergency interventions.
In all cases, recover emissions at source.
Prohibited equipment and procedures :
No smoking, eating or drinking in areas where the substance is used.
2. Conditions for safe storage, including any incompatibilities
Store in the original packaging. Keep away from moistures shelters.
Keep away from heat shelters - Recommended storage temperature : < 50 °C.
Storage
Keep the container tightly closed in a dry, well-ventilated place.
Keep away from food and drink, including those for animals.
Packaging
Always keep in packaging made of an identical material to the original.
1. Precautions for safe handling
Always wash hands after handling.
Remove and wash contaminated clothing before re-using.
Provide emergency showers and eye wash stations will be required in facilities where the substance is handled constantly.
Fire prevention :
Handle in well-ventilated areas.
Prevent access by unauthorised personnel.
Recommended equipment and procedures :
For personal protection, see section "Exposure controls/ Personal protection".
Observe precautions stated on label and also industrial safety regulations.
Never bring water into contact with this substance.
Do not breathe in dust.
Also provide breathing apparatus for certain short tasks of an exceptional nature and for emergency interventions.
In all cases, recover emissions at source.
Prohibited equipment and procedures :
No smoking, eating or drinking in areas where the substance is used.
2. Conditions for safe storage, including any incompatibilities
Store in the original packaging. Keep away from moistures shelters.
Keep away from heat shelters - Recommended storage temperature : < 50 °C.
Storage
Keep the container tightly closed in a dry, well-ventilated place.
Keep away from food and drink, including those for animals.
Packaging
Always keep in packaging made of an identical material to the original.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 3261
Shipping information
- Proper shipping name and description:
- CORROSIVE SOLID,ACIDIC, ORGANIC, N.O.S
- Chemical name:
- 3,4,5 trimethoxybenzoyl chloride
- Labels:
- 8
SpecialProvisionsopen allclose all
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 3261
Shipping information
- Proper shipping name and description:
- CORROSIVE SOLID,ACIDIC, ORGANIC, N.O.S
- Chemical name:
- 3,4,5 trimethoxybenzoyl chloride
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 3261
Shipping information
- Proper shipping name and description:
- CORROSIVE SOLID,ACIDIC, ORGANIC, N.O.S
- Chemical name:
- 3,4,5 trimethoxybenzoyl chloride
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
1. Controls parameters
Predicted no effect concentration (PNEC):
3,4,5 TRIMETHOXYBENZOYL CHLORIDE (CAS: 4521-61-3)
Environmental compartment: Decomposed by water with production of hydrochloric acid.
2. Exposure controls
Personal protection measures, such as personal protective equipment
Pictogram(s) indicating the obligation of wearing personal protective equipment (PPE).
Use personal protective equipment that is clean and has been properly maintained.
Store personal protective equipment in a clean place, away from the work area.
Never eat, drink or smoke during use. Remove and wash contaminated clothing before re-using. Ensure that there is adequate ventilation,
especially in confined areas.
- Eye / face protection
Avoid contact with eyes.
Before handling powders or dust emission, wear mask goggles in accordance with standard EN166.
Prescription glasses are not considered as protection.
Provide eyewash stations in facilities where the product is handled constantly.
- Hand protection
Use suitable protective gloves that are resistant to chemical agents in accordance with standard EN374.
Gloves must be selected according to the application and duration of use at the workstation.
Protective gloves need to be selected according to their suitability for the workstation in question : other chemical products that may be
handled, necessary physical protections (cutting, pricking, heat protection), level of dexterity required.
- Body protection
Avoid skin contact.
Wear suitable protective clothing.
Wear suitable protective clothing and, in particular, an apron and boots. These items of clothing shall be maintained in good condition and cleaned after use.
Work clothing worn by personnel shall be laundered regularly.
After contact with the product, all parts of the body that have been soiled must be washed.
- Respiratory protection
Avoid breathing dust.
If the ventilation is insufficient, wear appropriate breathing apparatus. When workers are confronted with concentrations that are above occupational exposure limits, they must wear a suitable, approved,respiratory protection device.
Wear a disposable half-mask dust filter in accordance with standard EN149.
Predicted no effect concentration (PNEC):
3,4,5 TRIMETHOXYBENZOYL CHLORIDE (CAS: 4521-61-3)
Environmental compartment: Decomposed by water with production of hydrochloric acid.
2. Exposure controls
Personal protection measures, such as personal protective equipment
Pictogram(s) indicating the obligation of wearing personal protective equipment (PPE).
Use personal protective equipment that is clean and has been properly maintained.
Store personal protective equipment in a clean place, away from the work area.
Never eat, drink or smoke during use. Remove and wash contaminated clothing before re-using. Ensure that there is adequate ventilation,
especially in confined areas.
- Eye / face protection
Avoid contact with eyes.
Before handling powders or dust emission, wear mask goggles in accordance with standard EN166.
Prescription glasses are not considered as protection.
Provide eyewash stations in facilities where the product is handled constantly.
- Hand protection
Use suitable protective gloves that are resistant to chemical agents in accordance with standard EN374.
Gloves must be selected according to the application and duration of use at the workstation.
Protective gloves need to be selected according to their suitability for the workstation in question : other chemical products that may be
handled, necessary physical protections (cutting, pricking, heat protection), level of dexterity required.
- Body protection
Avoid skin contact.
Wear suitable protective clothing.
Wear suitable protective clothing and, in particular, an apron and boots. These items of clothing shall be maintained in good condition and cleaned after use.
Work clothing worn by personnel shall be laundered regularly.
After contact with the product, all parts of the body that have been soiled must be washed.
- Respiratory protection
Avoid breathing dust.
If the ventilation is insufficient, wear appropriate breathing apparatus. When workers are confronted with concentrations that are above occupational exposure limits, they must wear a suitable, approved,respiratory protection device.
Wear a disposable half-mask dust filter in accordance with standard EN149.
Stability and reactivity
1. Reactivity
This substance reacts violently with water.
2. Chemical stability
This substance is stable under the recommended handling and storage conditions in section 7.
3. Possibility of hazardous reactions
No data available.
4. Conditions to avoid
Avoid :
- humidity
Protect from moisture. Reaction with water can cause an exothermic reaction.
5. Incompatible materials
Keep away from :
- water
Reacts violently with water.
6. Hazardous decomposition products
The thermal decomposition may release/form :
- carbon monoxide (CO)
- carbon dioxide (CO2)
- hydrogen chloride (HCl)
This substance reacts violently with water.
2. Chemical stability
This substance is stable under the recommended handling and storage conditions in section 7.
3. Possibility of hazardous reactions
No data available.
4. Conditions to avoid
Avoid :
- humidity
Protect from moisture. Reaction with water can cause an exothermic reaction.
5. Incompatible materials
Keep away from :
- water
Reacts violently with water.
6. Hazardous decomposition products
The thermal decomposition may release/form :
- carbon monoxide (CO)
- carbon dioxide (CO2)
- hydrogen chloride (HCl)
Disposal considerations
Proper waste management of the substance and/or its container must be determined in accordance with Directive 2008/98/EC.
1. Waste treatment methods
Do not pour into drains or waterways.
Waste :
Waste management is carried out without endangering human health, without harming the environment and, in particular without risk to water,
air, soil, plants or animals.
Recycle or dispose of waste in compliance with current legislation, preferably via a certified collector or company.
Do not contaminate the ground or water with waste, do not dispose of waste into the environment.
Soiled packaging :
Empty container completely. Keep label(s) on container.
Give to a certified disposal contractor.
1. Waste treatment methods
Do not pour into drains or waterways.
Waste :
Waste management is carried out without endangering human health, without harming the environment and, in particular without risk to water,
air, soil, plants or animals.
Recycle or dispose of waste in compliance with current legislation, preferably via a certified collector or company.
Do not contaminate the ground or water with waste, do not dispose of waste into the environment.
Soiled packaging :
Empty container completely. Keep label(s) on container.
Give to a certified disposal contractor.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
