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Diss Factsheets
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EC number: 224-167-6 | CAS number: 4221-98-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity
The LD50 of the test substance was determined to be 5700 mg/kg bw.
Acute dermal toxicity
In the acute dermal toxicity study the LD50 was determined to be greater than 5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is not GLP compliant but equivalent to guideline.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 to 250 g
- Fasting period before study: 16 hours
- Diet: Ad libitum
- Water: Ad libitum - Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 3200, 4000, 5000, 6250 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: For mortality at 1 and 6 hours and daily thereafter
- Necropsy of survivors performed: yes - Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 4 700 - < 6 700
- Mortality:
- Dosis - Number of died animals from 10
4000 mg/kg bw ; 2/10
5000 mg/kg bw; 5/10
6250 mg/kg bw; 7/10 - Clinical signs:
- The rats experienced lethargy and slow respiration.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test substance was determined to be 5700 mg/kg bw.
- Executive summary:
In the non-GLP compliant but guideline similar acute oral toxicity test with rats the following doses were tested 3200, 4000, 5000, 6250 mg/kg bw. 10 Wistar rats were used per dose.
The animals were observed for 14 days and necropsy of survivors was performed. The rats experienced lethargy and slow respiration. The LD50 of the test substance was determined to be 5700 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 700 mg/kg bw
- Quality of whole database:
- The study is not GLP compliant but equivalent to OECD guideline.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is not GLP compliant but equivalent to guideline.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.9 to 2.4 kg - Type of coverage:
- occlusive
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Erythema and edema signs: Daily; Weights: pre-and post treatment
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs - Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- Yes, signs of dermal irritation were observed.
- Body weight:
- No significant changes
- Gross pathology:
- No abnormalities were noted at necropsy.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute dermal toxicity study the discriminating dose was determined to be > 5000 mg/kg bw.
- Executive summary:
In the non- GLP compliant but guideline similar acute dermal toxicity study New Zealand White rabbits were used. A dose of 5000 mg/kg bw was administrated 24 hours to the clipped abraded abdominal skin of ten rabbits.
Following exposure the binders were removed and observations made for mortality and toxic effects for a period of seven days.
No animals died during the course of the study. There was no evidence of toxicity from percutaneous absorption of the test substance. Signs of dermal irritation (erythema and edema) were observed until day 7.
No abnormalities were noted at necropsy.
All animals were essentially normal by the termination of the study. Therefore, the LD50 was determined to be > 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The study is not GLP compliant but equivalent to OECD guideline.
Additional information
Acute oral toxicity
In the non-GLP compliant but guideline similar acute oral toxicity test with rats the following doses were tested 3200, 4000, 5000, 6250 mg/kg bw. 10 Wistar rats were used per dose.
The animals were observed for 14 days and necropsy of survivors was performed. The rats experienced lethargy and slow respiration. The LD50 of the test substance was determined to be 5700 mg/kg bw.
Acute dermal toxicity
In the non GLP compliant but guideline similar acute dermal toxicity study New Zealand White rabbits were used. A dose of 5000 mg/kg bw was administrated 24 hours to the clipped abraded abdominal skin of ten rabbits.
Following exposure the binders were removed and observations made for mortality and toxic effects for a period of seven days.
No animals died during the course of the study. There was no evidence of toxicity from percutaneous absorption of the test substance. Signs of dermal irritation (erythema and edema) were observed until day 7.
No abnormalities were noted at necropsy.
All animals were essentially normal by the termination of the study. Therefore, the LD50 was determined to be greater than 5000 mg/kg bw.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008 (oral)
Based on the results of the acute oral toxicity LD 50 = 5700 mg/kg bw the substance is not considered to be classified for acute oral toxicity under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008 (dermal)
Based on the results of the acute dermal toxicity LD50 > 5000 mg/kg bw the substance is not considered to be classified for acute dermal toxicity under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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