(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 03 January 2018 to 31 January 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

EC Number:

615-206-1

Cas Number:

709031-45-8

Molecular formula:

C6H10N2O.CH4O3S

IUPAC Name:

(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

Test material form:

solid

Details on test material:

- Appearance: Light tan solid
- Storage conditions: At room temperature protected from light

Specific details on test material used for the study:

Decomposition during melting (at 195°C).

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

20 °C

Vapour pressure:

< 0 Pa

Vapour pressure 2

Key result

Temp.:

25 °C

Vapour pressure:

< 0 Pa

Any other information on results incl. tables

Table: Results of the Vapour pressure Isothermal TGA Analysis

Temperature [°C]	Weight loss [µg/min]	vT [g/cm2/h]	log vT	log PT	PT [Pa]
170	0.441252	5.27E-5	-4.28	-0.34	0.46
	0.433758	5.18E-5	-4.29	-0.35	0.45
180	1.10311	1.32´E-4	-3.88	0.17	1.5
	1.04389	1.25E-4	-3.90	0.14	1.4
190	6.40613	7.65E-4	-3.12	1.15	14
	6.31915	7.54E-4	-3.12	1.14	14

 

The log PT versus 1/T curve for the substance over the range 170 -190°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures. Since the weight loss of the test item at 170°C, 180°C and 190°C was lower than the weight loss of reference substance chrysene at the same temperatures, it was considered that the vapour pressure of the substance at 20°C (25°C) is lower than the vapour pressure of chrysene at 20°C (25°C).

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance at 20°C was determined to be <8.4E-7 Pa.
The vapour pressure of the substance at 25°C was determined to be <6.6E-7 Pa.

Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. The log PT versus 1/T curve for the substance over the range 170 -190°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures.

From the measured weight losses in the temperature range 170 -190°C, the vapour pressure of the substance was determined to be lower than the vapour pressure of reference substance chrysene. The vapour pressure of the substance at 20°C and 25°C was concluded to be < 8.4E-7 Pa and < 6.6E-7 Pa, resp.