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Diss Factsheets
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EC number: 271-663-3 | CAS number: 68603-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no analytical monitoring carried out due to absence of valid method
- Justification for type of information:
- Refer to the section 13 of IUCLID dataset for details on the read across justification. The short term toxicity study to fish with the read across substance is considered sufficient to fulfil the information requirements as further explained in the provided endpoint summary.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- not specified
- Remarks:
- The study was conducted in 1984 in a lab according to OECD Guideline 203, however no mention of GLP conditions were reported in the study report.
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- ethylene glycol monomethyl ether
- Details on test solutions:
- 500 mg of test substance were mixed with 30 mg ARKOPAL N 150 and made up to 50 mL with ethylene glycol monomethylether.
- Test organisms (species):
- other: Salmo gairdneri
- Details on test organisms:
- Length : 50.2 mm
Weight : 0.96 g
Loading : 0.6 g/L
Acclimatisation: 14 d
Supplier : P. Hohler / CH-4314 Zeiningen - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Hardness:
- 145 mg CaCO3/L
- Test temperature:
- 15 degree Celsius
- pH:
- 8.1
- Dissolved oxygen:
- 91-104 % saturation
- Nominal and measured concentrations:
- Nominal: 0, 0.58, 1, 1.8, 3.2 and 5.8 mg/L
- Details on test conditions:
- Vessels : Glass aquaria of 20 L filled with 15 L (36/22/25 cm)
Number of fishes: 10 fishes per concentration and control, 5 fishes per aquarium
Aeration: gentle aeration during the test
Lighting: Fluorescent light, 16 h daily
Measurements: pH, O2,temperature daily - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 5.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the study conditions, the nominal 96 h LC50 of the test substance in rainbow trout was determined to be 5.5 mg/L.
- Executive summary:
A study was conducted to determine the short term toxicity of the read-across substance amines, C11 -14 -branched alkyl, monohexyl and dihexyl phosphates to fish according to OECD Guideline 203. A static exposure study was conducted in rainbow trout (Salmo gairdneri) at nominal concentrations of 0, 0.58, 1, 1.8, 3.2 and 5.8 mg/L of the test substance. The test substance stock solution was prepared in ethylene glycol monomethyl ether. The analytical determination of the test concentrations was not possible due to unavailability of a valid method at the test facility. Ten test fish per concentration were used at a loading rate of 0.6 g/L in 15 L of water medium in glass aquarium of 20 L capacity. pH, O2 and temperature were monitored throughout the 96 h exposure duration. Under the study conditions, the nominal 96 h LC50 of the test substance in rainbow trout was determined to be 5.5 mg/L (Rufli, 1984).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.5 mg/L
Additional information
A study was conducted to determine the short term toxicity of the read-across substance amines, C11 -14 -branched alkyl, monohexyl and dihexyl phosphates to fish according to OECD Guideline 203. A static exposure study was conducted in rainbow trout (Salmo gairdneri) at nominal concentrations of 0, 0.58, 1, 1.8, 3.2 and 5.8 mg/L of the test substance. The test substance stock solution was prepared in ethylene glycol monomethyl ether. The analytical determination of the test concentrations was not possible due to unavailability of a valid method at the test facility. Ten test fish per concentration were used at a loading rate of 0.6 g/L in 15 L of water medium in glass aquarium of 20 L capacity. pH, O2 and temperature were monitored throughout the 96 h exposure duration. Under the study conditions, the nominal 96 h LC50 of the test substance in rainbow trout was determined to be 5.5 mg/L (Rufli, 1984).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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