Registration Dossier
Registration Dossier
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EC number: 215-264-4 | CAS number: 1317-34-6
Endpoint summary
Administrative data
Description of key information
No experimental data for the target substance dimanganese trioxide are available. Therefore, data from manganese dioxide, a chemical substance that is structurally similar, with similar physico-chemical characteristics were used to describe the ecotoxicity profile of dimanganese trioxide. For details on the read across justification refer to the read across statement in IUCLID section 13.
Three trophic levels (fish, daphnia, algae) are covered by the acute toxicity data set and can be used for hazard assessment since chronic data are not available.
All tests show that under the conditions of the respective studies there were no toxic effects at a 100% v/v saturated solution of manganese dioxide to fish, aquatic invertebrates and algae. Since no hazard could be identified for the source substance manganese dioxide, no toxic effects of dimanganese trioxide to aquatic organisms are expected.
Additional information
The ecotoxicology of dimanganese trioxide can be understood in terms of the ecotoxicology of manganese dioxide. The acute toxicity of manganese dioxide was experimentally determined for various aquatic organisms according to different standardised methods:
Fish:
Goodband & Mullee 2010 (OECD 203, EU Method C.1): Under the conditions of the valid study reported by Goodband & Mullee (2010), the acute toxicity of manganese dioxide to the freshwater fish Oncorhynchus mykiss has been investigated and gave a 96-hour LC50 value of greater than 100% v/v saturated solution. Correspondingly the No Observed Effect Concentration was 100% v/v saturated solution. This information is used in a read-across approach in the assessment of the target substance dimanganese trioxide.
Invertebrates:
Goodband & Mullee 2010 (OECD 202, EU Method C.2): Under the conditions of the valid study reported by Goodband & Mullee (2010), the acute toxicity of manganese dioxide to the freshwater invertebrates Daphnia magna has been investigated and gave a 48-hr EC50 of greater than 100% v/v saturated solution. Correspondingly the No Observed Effect Concentration was 100% v/v saturated solution. This information is used in a read-across approach in the assessment of the target substance dimanganese trioxide.
Algae:
Vryenhoef & Mullee 2010 (OECD 201, EU Method C.3): Under the conditions of the valid study reported by Vryenhoef & Mullee (2010), the effect of manganese dioxide on the growth of Desmodesmus subspicatus has been investigated and gave EC50 values of greater than 100% v/v saturated solution. Correspondingly the No Observed Effect Concentration (NOEC) was 100% v/v saturated solution. This information is used in a read-across approach in the assessment of the target substance.
Microorganisms:
Youngs 2010 (OECD 209, EU Method C.11, EPA OPPTS 850.6800):
The EC50 for respiration inhibition of sewage sludge by manganese dioxide was determined to be above 1000 mg/L (Youngs 2010, OECD 202).
ln conclusion, under the conditions of the test by Youngs (2007), manganese dioxide was not toxic to activated sludge bacteria at a concentration of 1000 mg/L.
This information is used in a read-across approach in the assessment of the target substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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