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EC number: 227-645-2 | CAS number: 5921-65-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis
Hydrolysis of Caprinoguanamine is not expected under environmental conditions.
Biodegradation
Caprinoguanamine is considered to be not readily biodegradable based on QSAR prediction.
Adsorption
The Soil Adsorption Coefficients Koc of 4111 L/kg obtained from QSAR prediction was used for chemical safety assessment of Caprinoguanamine.
Additional information
Hydrolysis
Degradation by hydrolysis of Caprinoguanamine is not expected under environmental conditions based on its structure, supported by data from structural closely related substances.
Measured data on hydrolysis are available from OECD 111 guideline studies with Acetoguanamine and Benzoguanamine. In both studies measurements at pH values of 4, 7 and 9 show no significant changes in the concentration of the test item within five days. Both, Acetoguanamine and Benzoguanamine were proven to be hydrolytically stable.
Biodegradation
The generally accepted QSAR model BIOWIN for predicting biodegradability of Caprinoguanamine was used. Biowin (Version 4.10) predicts that Caprinoguanamine is not readily biodegradable.
This prediction is in line with the expected property, based on information from structural similar substances.
Data from biodegradability studies on the triazine derivates Acetoguanamine and Benzoguanamine are available. Both substances were tested according to OECD Guideline 301 E, the modified Screening Test.
No significant biodegradation within 28 days was found in the test bottles with Benzoguanamine.
As well no biodegradability was found in the test bottles with Acetoguanamine. Further it could be shown, that the degradation of Acetoguanamine was not increased in the absence of nitrogen.
Taken together both substances were proven to be not readily biodegradable under the given test conditions.
Melamine another structural similar triazine derivate was described to be not readily biodegradable within the OECD SIDs evaluation program of Melamine available at: http://www.inchem.org/documents/sids/sids/108781.pdf.
In conclusion the Biowin prediction “Caprinoguanamine is not readily biodegradable” is considered to be valid, taken into account the information from structurally similar substances.
Adsorption
The following Soil Adsorption Coefficients were predicted by QSAR model KOCWIN v2.00 for Caprinoguanamine:
Koc : 4111 L/kg (MCI method)
Log Koc: 3.614 (MCI method)
Koc : 752.4 L/kg (Kow method)
Log Koc: 2.876 (Kow method)
For chemical safety assessment Koc of 4111 L/kg from MCI method was considered the most appropriate as this method is somewhat more accurate than the Log Kow methodology.
Furthermore this value poses the worst case.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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