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EC number: 931-227-1 | CAS number: 28497-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28.09.1999 to 02.11.1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Reaction mass of 2-hydroxy-1,3-propanediyl bismethacrylate and 101525-90-0
- EC Number:
- 931-227-1
- Cas Number:
- 28497-59-8
- Molecular formula:
- C11H16O5
- IUPAC Name:
- Reaction mass of 2-hydroxy-1,3-propanediyl bismethacrylate and 101525-90-0
- Reference substance name:
- 2,3-dihydroxypropyl methacrylate
- EC Number:
- 227-642-6
- EC Name:
- 2,3-dihydroxypropyl methacrylate
- Cas Number:
- 5919-74-4
- Molecular formula:
- C7H12O4
- IUPAC Name:
- 2,3-dihydroxypropyl methacrylate
- Reference substance name:
- Glycerol trimethacrylate
- EC Number:
- 231-004-2
- EC Name:
- Glycerol trimethacrylate
- Cas Number:
- 7401-88-9
- Molecular formula:
- C15H20O6
- IUPAC Name:
- propane-1,2,3-triyl tris(2-methylacrylate)
- Reference substance name:
- oxybis(propane-2,1,3-triyl) tetrakis(2-methylacrylate)
- Molecular formula:
- C22H30O9
- IUPAC Name:
- oxybis(propane-2,1,3-triyl) tetrakis(2-methylacrylate)
- Reference substance name:
- Benzyl methacrylate
- EC Number:
- 219-674-4
- EC Name:
- Benzyl methacrylate
- Cas Number:
- 2495-37-6
- Molecular formula:
- C11H12O2
- IUPAC Name:
- benzyl methacrylate
- Reference substance name:
- Methacrylic acid
- EC Number:
- 201-204-4
- EC Name:
- Methacrylic acid
- Cas Number:
- 79-41-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- 2-methylprop-2-enoic acid
- Reference substance name:
- Mequinol
- EC Number:
- 205-769-8
- EC Name:
- Mequinol
- Cas Number:
- 150-76-5
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 4-methoxyphenol
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
additive 1
- Specific details on test material used for the study:
- Batch No. 790703330
Lot No.: 32079184
Reactive ester content: 96.9%
Glycerol dimethacrylate: 90.5%
Glycerol trimethacrylate: 1.5%
Storage: room temperature, protected from light
Stability: 6 months from date of delivery
Expiry Date: 99-09-09
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Hsd:Wistar rats (HsdBrl:WH,Full-Barrier), Sex: male and female, body weight at the commencement of the study: female 143 - 155 g and male 154 - 168 g. 3 male and 3 female animals were used.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test item 'vas administered in a single dose by gavage using a intubation cannula.
Volume of application: The test item was applied according to body-weight at a volume of 10ml/kg BW. - Doses:
- The starting dose was 2000 mg/kg body weight. Since no presence of compound-related mortality of the animals was observed no further testing was required.
- No. of animals per sex per dose:
- Two groups of 3 male and 3 female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were weighed prior to first application and once a week thereafter. A careful clinical examination was made twice a day on the day of dosing
and once a day thereafter. Cageside observations included changes in the skin and fur, eyes and mucous membranes. Also respiratory, circulatory, autonomic and central nervous systems and somatomotor activity and behaviour pattern were examined.
Particular attention was directed to observations of tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no effects observed
- Clinical signs:
- no effects observed
- Body weight:
- no effects observed
- Gross pathology:
- no effects observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Considering the reported data of this toxicity test it can be stated that the test item Glycerol dimethacrylate has no acute toxic characteristics.
The LD50 was determined to be > 2000 mg/kg bw; no clinical signs or body weight effects were observed.. - Executive summary:
In an acute oral toxicity study according to OECD guideline 423 (acute toxic class method), a group of male and female Wistar rats were given a single oral (gavage) dose of Glycerol dimethacrylate at a dose of 2000 mg/kg bw and observed for 14 days.
A careful clinical examination was made once a day. At the end of the observation period the animals were sacrificed and necropsy was carried out to record gross pathological changes.
A maximum dosage of 2000 mg/kg bw according to the acute toxic class method regime, caused no compound related mortality within 14 days post application. No clinical signs of toxicity were observed throughout the observation period.
Therefore the oral LD50 (combined) was determined to be > 2000 mg/kg bw.
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