Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-833-1 | CAS number: 75-03-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
two in vitro studies on bacteria base on lead to classify iodoethan as a substance suceptible to be mutagenic.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- GLP compliance:
- no
- Species / strain:
- E. coli WP2 uvr A
- Genotoxicity:
- positive
- Conclusions:
- positive result on an E Coli Bacteria
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Species / strain:
- S. typhimurium TA 1535
- Genotoxicity:
- positive
- Species / strain:
- S. typhimurium TA 100
- Genotoxicity:
- positive
- Species / strain:
- S. typhimurium TA 1537
- Genotoxicity:
- negative
- Species / strain:
- S. typhimurium TA 1538
- Genotoxicity:
- negative
- Species / strain:
- S. typhimurium TA 98
- Genotoxicity:
- negative
- Conclusions:
- positive mutagenicity on two bacteria, negative mutagenicity on three bacteria. The study results are not conclusive on Mutagenicity.
Referenceopen allclose all
Ames Salmonella/microsome test done with a chemically inert, closed incubation system for glass petri dishes thst allows vapour-phase head pace sampling.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Additional information
Justification for classification or non-classification
Two studies concluded to mutagenic effects on bacteria. on first study only two bacteria typhimurium bacteria are positive and three other negative. On the second study only one bacteria is tested. Iodomethane, chlorethane, and bromoethane harmonized classification is carc 2.
Considering the studies result, the possible role of alkylation on mutagenicity and the classification of haloethane and iodomethane, Iodoethane is suspected to cause cancer. and is classified has Carc. 2
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
