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EC number: 255-578-9 | CAS number: 41892-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- (3-chloro-2-hydroxypropyl)dodecyldimethylammonium chloride
- EC Number:
- 255-578-9
- EC Name:
- (3-chloro-2-hydroxypropyl)dodecyldimethylammonium chloride
- Cas Number:
- 41892-01-7
- Molecular formula:
- C17H37ClNO.Cl
- IUPAC Name:
- (3-chloro-2-hydroxypropyl)dodecyldimethylammonium chloride
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: BOR: NMRI, (SPF Han)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Initail age at test: 5 weeks
Body weight at test; males 29-35g, females 24 - 31g.
Room temp: 22°C+/-2°C, Humidity 55% +/- 15%, Room lighting: 6 am - 6pm: artificial lighting, 6pm - 6am, natural light/dark rhythm.
Water; ad libitum (drinking water quality), Standard diet, ad libitum.
Administration / exposure
- Route of administration:
- intraperitoneal
- Details on exposure:
- Negative control group and test material control group animals were given a single intraperitoneal administration of 10.0 ml/kg body weight. Positive control group animals received a single administration of 10.0 ml/kg body weight by oral gavage. The negative control group animals recived physiological saline soltution (0.9%). The test material group animals received the maximum tolerated doses in respect of the micronucleus test, i.e. 21.5 mg/kg bw (males) and 31.6 mg/kg bw (females) of the test material dissolved in ad aqua injectablilia. Positive control group received 51.1 mg/kg bw cyclophosphamide dissolved in physiological saline solution (0.9%).
- Post exposure period:
- 96hr
- No. of animals per sex per dose:
- Negative and poitive controls groups contained 18 males and 18 females. Test group contained 21 males and 21 females.
- Control animals:
- yes
Results and discussion
Test results
- Key result
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- QUAB 342 related toxic symptoms were observed in all test material group animals, including clonic convulsions, stilted gait, ruffled furs, ptosis, sunken sides and hypokinesia.
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- The test substance induced no chromosome mutation in mice by damage to the chromosomes or the miotic apparatus, at 24-, 48- or 72 hour intervals after the animals received a single intraperitoneal dose of 21.5 mg/kg body weight (males) and 31.6 mg/kg body weight (females). The substance is therefore considered non-mutagenic in the reported in vivo mouse micronucleus test.
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