Registration Dossier
Registration Dossier
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EC number: 210-723-5 | CAS number: 622-20-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017 to 2018
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of the test media were taken before initiation, before and after the test medium renewal and at termination. In the definitive test, the replicate test and control vessels were pooled.
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- In-house cultures orginially supplied by the University of Sheffield/UK. Single housed in 150 mL glass beakers containing ELendt M7 medium.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 18 to 22 +/-1°C
- Nominal and measured concentrations:
- Control and 100%v/v
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.015 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- An OECD 202 Guideline study was conducted with 1,1'-[ethane-1,2-diylbis(thio)]bisbenzene as a Limit Test. There was no mortality and the reported EC50 value is greater than the highest concentration tested at 100% v/v which resulted in a geometric mean mesured concentration of 0.0152 mg/L.
- Executive summary:
An OECD 202 guideline study was conducted with Daphnia magna exposed to the test material. Due to preliminary findings, the definitive study was conducted as at Limit Test at 100% v.v due to limited solubility. The reported EC50 value was greater than the highest concentration at 0.0152 mg/L based on the geometric mean measured values.
Reference
Description of key information
An OECD 202 Guideline study was conducted with 1,1'-[ethane-1,2-diylbis(thio)]bisbenzene as a Limit Test. There was no mortality and the reported EC50 value is greater than the highest concentration tested at 100% v/v which resulted in a geometric mean mesured concentration of 0.0152 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.015 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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