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Diss Factsheets
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EC number: 213-156-1 | CAS number: 927-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Screening level information. Information insufficient.
Data source
Referenceopen allclose all
- Reference Type:
- other: interoffice memo
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
- Reference Type:
- other: TSCA 8e submission
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- ; pre-guideline study. Only 2 dose levels were tested with an inappropriate spacing factor (100). No analytical dose monitoring. Test atmosphere generationis not clearly described.
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Test material form:
- aerosol dispenser: not specified
- Remarks:
- migrated information: aerosol
- Details on test material:
- - Physical state: clear liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Weight at study initiation: 205-230 g
- Housing: groups of 5 by sex in metal cages
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported but controlled
- Humidity (%): not reported but controlled
Administration / exposure
- Route of administration:
- inhalation: mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass chamber
- Exposure chamber volume: 59.1 L
- Method of holding animals in test chamber: rats were placed into subunits of 2 or 3 rats each
- System of generating aerosols: no details reported. Concentration was controlled by the air volume and the test substance flow (2.0 mg/L level: Havard Infusion Pump; 200 mg/L: Dow Dual Syringe Feeder)
TEST ATMOSPHERE
- Brief description of analytical method used: no measurements performed
- Samples taken from breathing zone: yes/no - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- approx. 2 mg/L and 200 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no details reported
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 - < 200 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: concentrations calculated
- Mortality:
- no mortality at 2 mg/L (0/10)
all rats died at 200 mg/L within 11 minutes following initiation of the exposure - Clinical signs:
- other: Groups at 2 mg/L: during exposure: decreased motor activity, erythema, salivation, lacrimation, clear nasal discharge, both ocular and nasal porphyrin discharge, tachypnea, dyspnea, gasping, soft stool, intermittent tonic convulsions, prostration. During
- Body weight:
- Groups at 2 mg/L: all rats gained body weight during the 14-day observation period
- Gross pathology:
- Groups at 200 mg/L: lungs were affected, see table below
Any other information on results incl. tables
Necropy findings in rats of groups at 200 mg/L: lungs were affected, see table below
Finding |
Incidence males |
Incidence females |
||
lungs |
congestion |
slight |
1/5 |
2/5 |
|
|
Moderate |
4/5 |
2/5 |
|
|
marked |
|
1/5 |
lungs |
oedematous |
|
5/5 |
5/5 |
Lungs, right cardia lobe consolidated |
|
|
1/5 |
|
Applicant's summary and conclusion
- Conclusions:
- Dimethylbutylamine is a strong respiratory irritant.
- Executive summary:
The acute inhalation toxicity was determined in CD-1 rats (5 per sex and dose) in a pre-guideline study without monitoring of the test substance concentration. All rats exposed at 2 mg/L survived until the end of the observation period while all rats exposed to nominal 200 mg/L died within 10 minutes after exposure initiation. Clinical signs indicated irritating effects both in the low dose and the high dose group (ocular and nasal discharge, corneal opacity in surviving animals; lung congestion and lung edema in victims). Thus the (LC50(4 hrs) was between 2 mg/L and 200 mg/l in this study (Wazeter and Goldenthal, 1975).
The study does not allow estimating the LC50-value. However, the described signs of toxicity clearly indicate that the primary mode of action is the irritating and corrosive effect of Dimethylbutylamine. The study is therefore considered to be supportive for assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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