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EC number: 480-060-6 | CAS number: 24065-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-10-28 to 2005-12-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 22. April 2002
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 480-060-6
- EC Name:
- -
- Cas Number:
- 24065-33-6
- Molecular formula:
- Hill formula: C5H3ClO2S CAS formula: C5H3ClO2S
- IUPAC Name:
- 5-chlorothiophene-2-carboxylic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- Esd:NZW
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories France, 69592 L’Arbresle, France
- Age at study initiation: young adult animals
- Weight at study initiation: 2.7 kg — 3.1 kg
- Housing: The animals were housed individually in cage units Metall/Noryl by EBECO. Excrement trays below the cages contained low dust wood granulate bedding (J. Rettenmaier & Söhne, 73494 Rosenberg, Germany).
- Diet (e.g. ad libitum): The animals received the standard diet “SsniffK-Z” 4mm (manufacturer: Ssniff Spezialdiäten GmbH, 59494 Soest, Germany), approximately 100 g per animal per day
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 50±25
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- pulverizede test item moistened with water
- Controls:
- other:
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 g - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: 0.5 g of the pulverized test substance moistened with Aqua p.i. (to ensure good contact with the skin) was applied to the skin of the animal under a gauze patch. The patch was placed on the dorso-lateral areas of the trunk of each animal and was held in place with non-irritating tape for the duration of the exposure period.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The exposed skin area was carefully washed with water without altering the existing response, or the integrity of the epidermis.
- Time after start of exposure: 4 h
OBSERVATION TIME POINTS
(indicate if minutes, hours or days): 1, 24, 48, 72 h
SCORING SYSTEM: The degree of erythema/eschar formation and oedema formation was recorded as specified by DRAIZE
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal: #1 - #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 - #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Other effects:
- - Other adverse local effects: not observed
- Other adverse systemic effects: not observed
Any other information on results incl. tables
Irritant Effects on the Skin (Exposure: 4 hours)
Animal 1, Body Weight 2.8 kg Observation (after patch removal) |
1 h |
24 h |
48 h |
72 h |
day 7 |
day 14 |
Erythema (redness) and eschar formation | 0 | 0 | 0 | 0 |
|
|
Oedema formation | 0 | 0 | 0 | 0 |
|
|
Animal 2, Body Weight 3.1 kg |
|
|
|
|
|
|
Observation (after patch removal) | 1 h | 24 h | 48 h | 72 h | day 7 | day 14 |
Erythema (redness) and eschar formation | 0 | 0 | 0 | 0 |
|
|
Oedema formation | 0 | 0 | 0 | 0 |
|
|
Animal 3, Body Weight 2.7 kg |
|
|
|
|
|
|
Observation (after patch removal) | 1 h | 24 h | 48 h | 72 h | day 7 | day 14 |
Erythema (redness) and eschar formation | 0 | 0 | 0 | 0 |
|
|
Oedema formation | 0 | 0 | 0 | 0 |
|
|
Summary of Irritant Effects (Score)
Animal |
| 24h | 48 h | 72 h | Mean scores | Response | Reversible (days) |
1 | Erythema (redness) and eschar formation | 0 | 0 | 0 | 0.0 | - | Na |
| Oedema formation | 0 | 0 | 0 | 0.0 | - | Na |
2 | Erythema (redness) and eschar formation | 0 | 0 | 0 | 0.0 | - | Na |
| Oedema formation | 0 | 0 | 0 | 0.0 | - | Na |
3 | Erythema (redness) and eschar formation | 0 | 0 | 0 | 0.0 | - | Na |
| Oedema formation | 0 | 0 | 0 | 0.0 | - | na |
no positive response : mean scores < 2 = - | |||||||
positive response :mean scores ≥ 2 = + | |||||||
na: not applicable |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The irritant / corrosive potential of 5-Chlorthiophen-2-carbonsäure was studied on the skin of rabbits. The method used complied with the OECD - Guideline for Testing of Chemicals No. 404 -" Acute Dermal Irritation/Corrosion"; adopted: 24th April 2002.
According to classification criteria 5-Chlorthiophen-2-carbonsäure is not an irritant to the skin. There were no systemic intolerance reactions. - Executive summary:
In a primary dermal irritation study according to OECD guideline 404 (2002), young adult New Zealand White rabbits (3/treatment) were dermally exposed to 0.5 g/patch of Clorthiphen-2-carbonsäure (100 % a.i.) for 4 hours to 5 cm² of shaved dorsal skin. Animals then were observed for 72 h according to the adopted guideline due to the absence of any irritant effect. Irritation was scored as required by the test guideline.
Under the present test conditions all three animals showed no erythema or oedema after patch removal.
All three animals also showed no oedema and erythema at the examination time-points 24 and 48 hours after patch removal.
Based on these results the test item does not need to be classified according to Regulation (EU) No. 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labelling of Chemicals (GHS) with respect to corrosivity.
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