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Physical & Chemical properties

Vapour pressure

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-05-02 to 2017-07-04
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Temp.:
25 °C
Vapour pressure:
0 Pa

Experiments 1-5 and 9 (nominal temperature 30 - 90 and 150 °C) showed no reproducible weight loss. Therefore, they were not used for calculation.

Table 2. Calculation Results Experiment 6

Experiment

6

 

 

 

 

 

 

 

 

Real Temperature in K

378.2

 

 

 

 

 

 

 

 

Real Temperature in °C

105.0

 

 

 

 

 

 

 

 

Date of Measurement

09.06.2017 11:25

13.06.2017 11:55

14.06.2017 11:50

Elapsed Time in s

81600

92700

83700

Parameter

Weight loss

to be used

Vapour pressure

Weight loss

to be used

Vapour pressure

Weight loss

to be used

Vapour pressure

Unit

g

yes/no

Pa

g

yes/no

Pa

g

yes/no

Pa

Knudsen-cell 1

0.00128

yes

5.52E-03

0.00099

yes

3.76E-03

0.00166

yes

6.98E-03

Knudsen-cell 2

0.00043

yes

1.85E-03

0.00080

yes

3.04E-03

0.00081

yes

3.40E-03

Knudsen-cell 3

0.00074

yes

3.19E-03

0.00078

yes

2.96E-03

0.00080

yes

3.36E-03

Knudsen-cell 4

0.00079

yes

3.41E-03

0.00141

yes

5.35E-03

0.00133

yes

5.59E-03

Mean

 

yes

3.49E-03

 

yes

3.78E-03

 

yes

4.83E-03

Standard deviation:

 

 

1.52E-03

 

 

1.11E-03

 

 

1.77E-03

Mean of measured values:

 

4.034E-03

 

 

 

 

 

 

Standard deviation:

 

7.069E-04

RSD:

17.5%

 

 

 

 

Table 3. Calculation Results Experiment 7

Experiment

7

 

 

 

 

 

 

 

 

Real Temperature in K

393.2

 

 

 

 

 

 

 

 

Real Temperature in °C

120.0

 

 

 

 

 

 

 

 

Date of Measurement

20.06.2017 11:55

21.06.2017 12:00

22.06.2017 12:00

Elapsed Time in s

88500

83400

83400

Parameter

Weight loss

to be used

Vapour pressure

Weight loss

to be used

Vapour pressure

Weight loss

to be used

Vapour pressure

Unit

g

yes/no

Pa

g

yes/no

Pa

g

yes/no

Pa

Knudsen-cell 1

0.00791

yes

3.21E-02

0.01313

yes

5.65E-02

0.01769

yes

7.61E-02

Knudsen-cell 2

0.00373

yes

1.51E-02

0.00678

yes

2.92E-02

0.00890

yes

3.83E-02

Knudsen-cell 3

0.00449

yes

1.82E-02

0.00669

yes

2.88E-02

0.01002

yes

4.31E-02

Knudsen-cell 4

0.00685

yes

2.78E-02

0.01118

yes

4.81E-02

0.01562

yes

6.72E-02

Mean

 

no

 

 

yes

4.06E-02

 

yes

5.62E-02

Standard deviation:

 

 

 

 

 

1.39E-02

 

 

1.83E-02

Mean of measured values:

 

4.839E-02

 

 

 

 

 

 

Standard deviation:

 

1.099E-02

RSD:

22.7%

 

 

 

 

If “no” is stated in the respective column: measurement was not considered for the calculation of the mean.

Table 4. Calculation Results Experiment 8

Experiment

8

 

 

 

 

 

 

 

 

Real Temperature in K

408.2

 

 

 

 

 

 

 

 

Real Temperature in °C

135.0

 

 

 

 

 

 

 

 

Date of Measurement

23.06.2017 12:35

27.06.2017 12:50

28.06.2017 12:10

Elapsed Time in s

85500

88800

84600

Parameter

Weight loss

to be used

Vapour pressure

Weight loss

to be used

Vapour pressure

Weight loss

to be used

Vapour pressure

Unit

g

yes/no

Pa

g

yes/no

Pa

g

yes/no

Pa

Knudsen-cell 1

0.11215

yes

4.79E-01

0.07249

yes

2.98E-01

0.06863

yes

2.96E-01

Knudsen-cell 2

0.06526

yes

2.79E-01

0.05348

yes

2.20E-01

0.04476

yes

1.93E-01

Knudsen-cell 3

0.07169

yes

3.06E-01

0.05846

yes

2.41E-01

0.05104

yes

2.20E-01

Knudsen-cell 4

0.09787

yes

4.18E-01

0.06233

yes

2.57E-01

0.05806

yes

2.51E-01

Mean

 

yes

3.71E-01

 

yes

2.54E-01

 

yes

2.40E-01

Standard deviation:

 

 

9.42E-02

 

 

3.32E-02

 

 

4.42E-02

Mean of measured values:

 

2.883E-01

 

 

 

 

 

 

Standard deviation:

 

7.174E-02

RSD:

24.9%

 

 

 

 

The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):

Table 5: Experimentally determined vapour pressure

Temperature Temperature Pressure Stand. Dev.
(Pressure)		 RSDP
°C K Pa Pa %
105.0 378.2 4.03E-03 7.07E-04 17.5%
120.0 393.2 4.84E-02 1.10E-02 22.7%
135.0 408.2 2.88E-01 7.17E-02 24.9%

In this table, E-0X represents multiplication with 10-X.

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

For the test item the vapour pressures at 20 °C and at 25 °C were calculated from the regression equation (see results above).

The linear regression of log P vs. 1/T gave a correlation coefficient r of - 0.9974, showing good repeatability and precision. Therefore, the determination is considered as valid.

Table 6: Parameters of linear regression

Parameter

Value

Slope

-9556.9

Intercept

22.9125

Correlation Coefficient r

-0.9974

Coefficient of Determination r2

0.9948
Conclusions:
For the test item the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
- at 20 °C: 2.05E-10 Pa
- at 25 °C: 7.22E-10 Pa
Executive summary:

A study was performed according to OECD TG 104 and Commission Regulation (EC) No. 440/2008 method A.4 by using the effusion method (weight loss). Decomposition of the test item was stated before boiling at a temperature of 219 °C. The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C). The experimentally determined vapour pressure results of 105, 120 and 135 °C were considered valid for determination of the vapour pressures at 20 °C and 25 °C from regression equation. The linear regression of log P vs. 1/T gave a correlation coefficient r of - 0.9974, showing good repeatability and precision. Therefore, the determination was considered as valid. For the test item the vapour pressures of 2.05 x 10-10 Pa at 20 °C and 7.22 x 10-10 Pa at 25 °C were calculated from the regression equation.

Description of key information

For the test item the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

- at 20 °C: 2.05E-10 Pa

- at 25 °C: 7.22E-10 Pa

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

A study was performed according to OECD TG 104 and Commission Regulation (EC) No. 440/2008 method A.4 by using the effusion method (weight loss). Decomposition of the test item was stated before boiling at a temperature of 219 °C. The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C). The experimentally determined vapour pressure results of 105, 120 and 135 °C were considered valid for determination of the vapour pressures at 20 °C and 25 °C from regression equation. The linear regression of log P vs. 1/T gave a correlation coefficient r of - 0.9974, showing good repeatability and precision. Therefore, the determination was considered as valid. For the test item the vapour pressures of 2.05 x 10-10 Pa at 20 °C and 7.22 x 10-10 Pa at 25 °C were calculated from the regression equation (reference 4.6-1).