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Diss Factsheets
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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OPPTS 870.3100 combined with micronucleus formation study
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- Ammonium perchlorate
- EC Number:
- 232-235-1
- EC Name:
- Ammonium perchlorate
- Cas Number:
- 7790-98-9
- Molecular formula:
- ClHO4.H3N
- IUPAC Name:
- ammonium perchlorate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 12 h light/ 12 h darc cycle; 22 +- 2 °C, 50 +- 15% relative humidity, 12 - 15 air changes/h; 2 weeks of acclimation time
Administration / exposure
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- 14 and 90 days, respectively
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (nominal)
- Remarks:
- control group
- Dose / conc.:
- 0.01 mg/kg bw/day (nominal)
- Dose / conc.:
- 0.05 mg/kg bw/day (nominal)
- Dose / conc.:
- 0.2 mg/kg bw/day (nominal)
- Dose / conc.:
- 1 mg/kg bw/day (nominal)
- Dose / conc.:
- 10 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 20 or 30, respectively
- Control animals:
- yes, concurrent no treatment
- Positive control(s):
- As a positive control material cyclophosphamide was used, administered by a single intraperitoneal injection (20 mg/kg bw).
Examinations
- Tissues and cell types examined:
- For all animals a complete gross necropsy examination after death or scheduled euthanasia was conducted. For each animal, a complete set of tissues and organs was preserved by immersion in 10% neutral buffered formalin. From the control-group and the high-dose-groupe animals euthanized after 14 or 90 days all tissues were examined microscopically. From all groups the livers, kidneys, lungs, thyroids and gross lesions were examined for histopathological changes.
Results and discussion
Test results
- Key result
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- test-material related effects on thyroid observed at a dose of 10 mg/kg/day
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- The positive control material (cyclophosphamide) induced a marked increase in micronucleated polychromatic erythrocyte.
Applicant's summary and conclusion
- Conclusions:
- No test-material-related changes in bone marrow micronucleus formation or polychromatic erythrocyte/normochromatic erythrocyte ratio were observed in both sex groups after 90 days of treatment at a dose of 10 mg/kg/day. The perchlorat moiety of ammonium perchlorate can be stated as non-genotoxic. As potassium perchlorate dissociated rapidly and potassium in known to be non-genotoxic, an eqivalent dose of 11.8 mg/kg/day potassium perchlorate can be stated as non-genotoxic.
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