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EC number: 208-867-9 | CAS number: 544-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 20, 2005 to June 17, 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
A closed bottle ready biodegradation study was performed to assess the ready biodegradability of the read across substance, amides, C16-18, N-(hydroxyethyl), with non-adapted municipal activated sludge according to OECD Guideline 301 D, in compliance with GLP. The test substance concentration was 3.33 mg/L, corresponding to 10.22 mg O2/L in the test vessel. Degradation was analysed by measuring the oxygen concentrations over a period of 28 d. Biodegradation was expressed as the percentage BOD and calculated for each oxygen analysis. Sodium acetate was used as the reference control at 10 mg/L. The test substance reached the 10% level (begin of degradation) after 2 d. The pass level of >60% was reached after 17 d. The degradation reached a maximum of 69% after 28 d. The biodegradation for the reference substance reached 68% after 14 d. All the validity criteria according to the guideline were fulfilled. Under the test conditions, the test substance was considered readily biodegradable (Fiebig, 2005).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- ; there was slight higher oxygen depletion in the inoculum control; however it has no impact on the quality and integrity of the study.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(2-hydroxyethyl)stearamide
- EC Number:
- 203-883-2
- EC Name:
- N-(2-hydroxyethyl)stearamide
- Cas Number:
- 111-57-9
- Molecular formula:
- C20H41NO2
- IUPAC Name:
- Amides, C16-18, N-(hydroxyethyl)
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, non-adapted
- Details on inoculum:
- -Source of inoculum/activated sludge: Municipal sewage treatment plant, D-31137 Hildesheim
-Pretreatment: The activated sludge was filtered with folded filter. The first 200 mL of the filtrate was not used. The second filtrate effluent from the domestic waste water was used to initiate inoculation.
-Colony forming units in the test vessels: 104-106 CFU/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 3.33 mg/L
- Based on:
- other: test concentration (i.e., equivalent to COD of 10.22 mgO2/L; ThOD of 9.03 mgO2/L )
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral nutrient solution according to to OECD 301 D
- Test temperature: 20-24 (constant ± 1°C)
- pH: 7.52
- Continuous darkness: yes, in an incubator
- Dispersion treatment: Agitation
TEST SYSTEM:
- Culturing apparatus: 300 mL BOD bottles with glass stoppers
- Number of culture flasks/concentration: Duplicates
- Method used to create aerobic conditions: Aerated until oxygen saturation
SAMPLING:
- Oxygen consumption was measured on Day 0, 7, 14, 21 and 28.
CONTROL AND BLANK SYSTEM
Inoculum control: Nutrient solution and inoculum
Toxicity control: 100 mL of test substance (1.67 mg/L) + 5 mg/L reference substance + nutrient solution and inoculum
PERFORMACE OF THE TEST: Based on the chemical oxygen demand (COD) the test concentration of 3.33 mg/L corresponding to oxygen demand of 10.22 mg O2 in the vessel was selected. Inoculum (0.2 mL) and test substance in a mineral culture medium were placed in closed flasks and kept at a constant temperature of 20-24 (constant +/- 1°C) in the dark in an incubator. Oxygen consumption of the inoculums control, functional control, test substance and toxicity control was determined.
Reference substance
- Reference substance:
- acetic acid, sodium salt
- Remarks:
- at 10 mg/L (ThOD = 0.78 mgO2/mg)
Results and discussion
- Preliminary study:
- None
- Test performance:
- No data
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 69
- Sampling time:
- 28 d
- Details on results:
- - Inoculum control: The oxygen demand in the inoculum control came to 2.11 mgO2/L after 28 d.
- Toxicity control: The biodegradation rate came to 51% after 14 d and reached 65% after 28 d.
BOD5 / COD results
- Results with reference substance:
- For the reference substance, the pass level of >60% was reached after 11 days. After 28 days, the biodegradation reached 74%.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- There was slight higher oxygen depletion (>1.5 mg O2/L) in the inoculum control; however it had no impact on the quality and integrity of the study.
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the test conditions, the test substance was considered to be readily biodegradable with 69% degradation after 28 d.
- Executive summary:
A closed bottle ready biodegradation study was performed to assess the ready biodegradability of the test substance with non-adapted municipal activated sludge according to OECD 301D. The test substance concentration was 3.33 mg/L, corresponding to 10.22 mg O2/L in the test vessel. Degradation was analysed by measuring the oxygen concentrations over a period of 28 days. The biodegradation is therefore expressed as the percentage BOD and was calculated for each oxygen analysis. Sodium acetate was used as the reference control at 10 mg/L. The test substance reached the 10% level (begin of degradation) after 2 days. The pass level of >60% was reached after 17 days. The degradation reached a maximum of 69% after 28 days. The biodegradation for the reference substance reached 68% after 14 days. All the validity criteria according to the guideline were fulfilled. Under the test conditions, the test substance was considered readily biodegradable (Fiebig, 2005).
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