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Diss Factsheets

Administrative data

Description of key information

LD50 of Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl ether was determined by acute toxicity study to be 730 mg/m3 (0.64 ml/kg bw).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April, 1977 to August, 1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
no guideline followed
Principles of method if other than guideline:
Curing agent 1115 was administered undiluted by oral intubation in a range of dosage volumes in the full scale test of 0.25 to 1.6 ml/kg bodyweight. Rats dosed with water (1.6 ml/kg) served as controls.
During the observation period of 14 days, a record was kept of all mortalities and signs of toxicity. All rats that died were examined macroscopically in an attempt to identify the target organs, and those
animals surviving terminally were similarly examined to detect possible residual damge.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
other: CFY
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
0.25, 0.4, 0.64, 1.0, 1.6 ml/kg
No. of animals per sex per dose:
5 animals per sex per dose
Control animals:
no
Details on study design:
Curing agent 1115 was administered undiluted by oral intubation in a range of dosage volumes in the full scale test of 0.25 to 1.6 ml/kg bodyweight. Rats dosed with water (1.6 ml/kg) served as controls.
During the observation period of 14 days, a record was kept of all mortalities and signs of toxicity. All rats that died were examined macroscopically in an attempt to identify the target organs, and those
animals surviving terminally were similarly examined to detect possible residual damge.
Statistics:
From the mortality data, the LD50 and its 95% confidence limits were calculated by the method Weil C.S., (1952), Biometries -8, 249.
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
0.64 mL/kg bw
Based on:
test mat.
95% CL:
> 0.47 - < 0.87
Sex:
male/female
Dose descriptor:
LD50
Effect level:
730 mg/kg bw
Based on:
test mat.
95% CL:
> 540 - < 990
Mortality:
Dose (ml/kg b.w.) Mortality male (deaths/dosed) Mortality female (deaths/dosed)
0.00 0/5 0/5
0.25 0/5 0/5
0.40 1/5 1/5
0.64 3/5 3/5
1.00 2/5 5/5
1.60 5/5 5/5

Clinical signs:
diarrhoea
irregular respiration
lethargy (hypoactivity)
salivation
other:
Gross pathology:
See Clinical signs section
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 of Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl ether was determined by acute toxicity study to be 730 mg/m3.
Executive summary:

LD50 of Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl ether was determined by acute toxicity study to be 730 mg/m3.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
730 mg/kg bw

Additional information

Justification for classification or non-classification

Based on the acute oral toxicity study, the test substance has to be classified with Acute Tox Oral 4 (H303) according to CLP regulation 1272/2008.