Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-715-1 | CAS number: 13466-20-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study, meeting scientific principles. Test method not fully documented.
- Qualifier:
- according to guideline
- Guideline:
- other: "Methods for acute toxicity tests with fish, macroinvertebrates and amphibians” U.S. EPA 1975.
- GLP compliance:
- not specified
- Vehicle:
- no
- Details on test solutions:
- Test concentrations were prepared by direct addition of weighed amounts of test material to seawater or by pipetting appropriate volumes of weighed amounts of test material mixed with solvent/carrier.
- Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- TEST ORGANISM
- Common name: Sheepshead minnow
- Source: hatched and reared at study site or obtained form EPA's Envrion. Research Lab. Fulf Breese, USA
- Age at study initiation (mean and range, SD): 14 - 28 days
- Length at study initiation (length definition, mean, range and SD): 8 - 15 mm
- Feeding during test: no
ACCLIMATION
- Acclimation conditions (same as test or not): salinity of seawater 10-31 ‰, temperature 25 - 31 °C
- Type and amount of food: Artemia salina nauplii
- Feeding frequency: daily
- Health during acclimation (any mortality observed): mortality <3% - Test type:
- static
- Water media type:
- saltwater
- Total exposure duration:
- 96 h
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass jars (either 4-L glass jars containing 3 L of test solution or 19-L glass jars containing 15 L.
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: filtered natural seawater of ambient salinity.
- Intervals of water quality measurement: oxygen concentration was measured daily, pH was measured at test start and termnation.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
mortality after 24, 48, 72 and 96 hours. - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Aucte toxicity test (96 h) conducted with wild cought fish at low (3 - 8 ppt) and high salinity (17-23 ppt).
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Test organisms (species):
- Fundulus heteroclitus
- Details on test organisms:
- TEST ORGANISM
- Common name: of
- Source: collected from areas in New Jersey, included Shark River, Shrewsbury River and Horseshoe Cove at Sandy Hook, USA
- Weight at study initiation (mean and range, SD): 1.1 - 6.0 g
ACCLIMATION
- Acclimation period: ≥3 days
- Acclimation conditions (same as test or not): same. Acclimation in either waters of low salinities (3 to 8 ppt) or high salinities (17 to
23 ppt) in water obtained from either Horseshoe Cove or from the ocean off Asbury Park, New Jersey, USA. The natural waters were diluted with tap water in order to obtain the required salinity. - Test type:
- static
- Water media type:
- brackish water
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 20°C
- Salinity:
- low (3 - 8 ppt) and high salinity (17-23 ppt)
- Nominal and measured concentrations:
- Nominal test substance concentration: 1, 10, 100 and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 3.7 L glass vessels
- No. of organisms per vessel: 3
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: waters of low salinities (3 to 8 ppt) or high salinities (17 to 23 ppt) in water obtained from either Horseshoe Cove or from the ocean off Asbury Park, New Jersey, USA. The natural waters were diluted with tap water in order to obtain the required salinity.
OTHER TEST CONDITIONS
- Photoperiod: Natural lighting allowed a normal day-night regime.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality after 24, 48, 72 and 96 h - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: salinity 6 ppt
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: salinity 22 ppt
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Please refer to the analogue justification attached to chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- please refer to the analogue justification attached to chapter 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: salinity 6 ppt
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: salinity 22 ppt
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of barium bis(dihydrogen orthophosphate) to fish are not available. The assessment was therefore based on experimental data on barium sulphate and barium chloride dehydrate. The read across approach is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5.. An acute toxicity on the read across substance barium chloride determined not detrimental effects on fish (Dorfman, 1977). The study was conducted with Fundulus heteroclitus (mummichog) in saltwater of high and low salinity, respectively. The test fish were exposed to substance concentrations of 1 – 1000 mg/L for 96 hours. The tolerance of the test fish to barium chloride was assessed by determining the mortality. After 96 h a LC50 >1000 mg/L was determined.
The second available read across study was conducted with barium (the salt is not stated in the report). The study was conducted according to “Methods for acute toxicity tests with fish, macroinvertebrates and amphibians” U.S. EPA 1975. The test species Cyprinodon variegatus was exposed for 96 hours in natural seawater. A LC50 >500 mg/L was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.