Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-937-5 | CAS number: 112-12-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- Data is from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study of Methyl nonyl ketone (112-12-9) in rabbit
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials: Menthone Racemic
- Author:
- D. L. J. Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology,Volume 13, Issue 6, 1975, Pages 869-870
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study in rabbit for CAS no: 112-12-9
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- Gestis Substance Database ,2018
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study of Methyl nonyl ketone (112-12-9)
- Author:
- MaryAdele J’o Neil
- Year:
- 2 006
- Bibliographic source:
- The Merck Index, 14th Edition,Pg 6100, 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Undecan-2-one
- EC Number:
- 203-937-5
- EC Name:
- Undecan-2-one
- Cas Number:
- 112-12-9
- Molecular formula:
- C11H22O
- IUPAC Name:
- undecan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): Methyl nonyl ketone
- Common name: 2-Undecanone
- Molecular formula: C11H22O
- Molecular weight: 170.294 g/mol
- Smiles notation: C(CCCCCC)CCC(C)=O
- InChl: 1S/C11H22O/c1-3-4-5-6-7-8-9-10-11(2)12/h3-10H2,1-2H3
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 4 animals/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed for mortality and systemic effects over a 14 day period.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at dose 5000 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The lethal concentration (LD50) value for acute dermal toxicity test was considered to be >5000 mg/kg bw,when rabbits were treated with test chemical Methyl nonyl ketone via dermal route.
- Executive summary:
Acute dermal toxicity study was performed in rabbits using test chemical Methyl nonyl ketone (CAS no.: 112 -12 -9, E.C. no.: 203 -937 -5). 4male and 4female rabbits were treated at a dose concentration of 5000mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality. No mortality was observed at dose 5000 mg/kg bw. Hence, the LD50 value was considered to be >5000mg/kg bw,when rabbits were treated with test chemical Methyl nonyl ketone via dermal route. The test chemical can be considered as "Not classified" according to the CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.