Alcohols, C8-18, ethoxylated

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two short term toxicity study of aquatic invertebrate for the test chemical :
1 . and 2. To evalute the toxicity of test chemical on aquatic invertebrate.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: 1. Gammarus italicus, 2. Daphnia magna

Details on test organisms:

1. Male individuals, kept for about three days in "artificial water" (5) at a constant temperature of 8°C, received artificial oxygentation and were fed on
dry poplar leaves previously soaked in spring water in order to enrich them with fungi and bacteria.Feeding was suspended 24 h before experiments.

2.

Test type:

static

Water media type:

freshwater

Total exposure duration:

24 h

Hardness:

1. 240 mgl'1 as CaCO3

Test temperature:

1. 8 deg.C

pH:

1. 8.1
2. 8

Details on test conditions:

1. Those individuals which, after 24 h, when gently prodded with a spatula showed no movements of the pleopodes were considered dead. During the test,carried out in static conditions at the temperature of 8°C and without oxygentation, the animals were not fed.

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

9.45 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: Read across 1

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

3 200 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

behaviour

Remarks on result:

other: Read across 2

Conclusions:

The test chemical Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is not likely to be toxic to aquatic inverbrate at least in the dose range of 9.45-3200 mg/l.

Executive summary:

Following studies of structurally and functionally similar read across has ben assessed to conclude the toxicity extent of Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) towards aquatic invertebrate is summarized as follows:

1. The lethal concentration (LC50) value of Dodecan-1-ol, ethoxylated in aquatic invertebrates (Gammarus italicus) in a 24 hr study on mortality effect was found to be 9.45 mg/L. The BCF value of Dodecan-1-ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

2. Short term toxicity to aquatic invertebrate test was carried out for 24 h on aquatic invertebrate to study the effects of 2-(2-butoxyethoxy)ethanol.Effective concentration to 50% of Daphnia magna when exposed to 2-(2-butoxyethoxy)ethanol for 24 hr is 3200 mg/L. It can be concluded from the value that the 2-(2-butoxyethoxy)ethanol is no toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.

Description of key information

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) towards aquatic invertebrate is summarized as follows:

1. The lethal concentration (LC50) value of Dodecan-1-ol, ethoxylated in aquatic invertebrates (Gammarus italicus) in a 24 hr study on mortality effect was found to be 9.45 mg/L. The BCF value of Dodecan-1-ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

2. Short term toxicity to aquatic invertebrate test was carried out for 24 h on aquatic invertebrate to study the effects of 2-(2-butoxyethoxy)ethanol.Effective concentration to 50% of Daphnia magna when exposed to 2-(2-butoxyethoxy)ethanol for 24 hr is 3200 mg/L. It can be concluded from the value that the 2-(2-butoxyethoxy)ethanol is no toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

3 200 mg/L

Additional information

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) towards aquatic invertebrate is summarized as follows:

1. The lethal concentration (LC50) value of Dodecan-1-ol, ethoxylated in aquatic invertebrates (Gammarus italicus) in a 24 hr study on mortality effect was found to be 9.45 mg/L. The BCF value of Dodecan-1-ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

2. Short term toxicity to aquatic invertebrate test was carried out for 24 h on aquatic invertebrate to study the effects of 2-(2-butoxyethoxy)ethanol.Effective concentration to 50% of Daphnia magna when exposed to 2-(2-butoxyethoxy)ethanol for 24 hr is 3200 mg/L. It can be concluded from the value that the 2-(2-butoxyethoxy)ethanol is no toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.