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EC number: 209-667-4 | CAS number: 589-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from peer reviewed journal
- Justification for type of information:
- data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: refer principle below
- Principles of method if other than guideline:
- Biodegradation rate constant of test chemical 3-Octanol was determined by using activated sludge as inoculums and test material analysis by GC as parameter.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 3-Octanol
- IUPAC name: Octan-3-ol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mole
- Smiles : C([C@@H](CC)O)CCCC
- Inchl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid - Oxygen conditions:
- not specified
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Activated sludge was obtained at the end of an aeration period from the semi-continuous culture maintained with peptone-glucose synthetic waste in the laboratory. After washing with a M/50 phosphate buffer ( pH 7 ) it was used in the experiments
- Initial conc.:
- 0.05 other: mL/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- GC
- Details on study design:
- TEST CONDITIONS
- Composition of medium: 81.5 mg of KH2P04, 196 mg of Na2HPO4, 10 mg of MgSO47H20 , 1.0 mg of FeSO47H20 , 10 mg of urea, 2.0 m% of ethanol, and water.
- Test temperature: 25 ± 1 °C.
TEST SYSTEM
- Culturing apparatus: 200 mL Erlenmeyer - Parameter:
- other: Rate consant by test material analysis
- Value:
- 905
- Remarks on result:
- other: rate constant 905 /hr
- Details on results:
- Biodegradation rate constant of test chemical 3-Octanol was determined to be 905 per hrs.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- other: Biodegradable
- Conclusions:
- Biodegradation rate constant of test chemical 3-Octanol was determined to be 905 per hrs by using activated sludge as inoculums and test material analysis by GC as parameter. On the basis of this rate constant value it can be concluded that test chemical is biodegradable.
- Executive summary:
An experiment was conducted to determine biodegradation rate constant of test chemical 3-octanol (CAS no. 589-98-0) in this experiment activated sludge was obtained at the end of an aeration period from the semi-continuous culture maintained with peptone-glucose synthetic waste in the laboratory. After washing with a M/50 phosphate buffer ( pH 7 ) it was used in the experiments. Following medium was used 81.5 mg of KH2P04, 196 mg of Na2HPO4, 10 mg of MgSO47H20 , 1.0 mg of FeSO47H20 , 10 mg of urea, 2.0 m% of ethanol, and water in 200 mL Erlenmeyer flask concentration of test chemical used was 0.05 ml/L. Then test material was anlyzed by gaschromatography.Biodegradation rate constant of test chemical 3-Octanol was determined to be 905 per hrs by using activated sludge as inoculums and test material analysis by GC as parameter. On the basis of this rate constant value it can be concluded that test chemical is biodegradable.
Reference
Description of key information
Biodegradation rate constant of test chemical 3-Octanol was determined to be 905 per hrs by using activated sludge as inoculums and test material analysis by GC as parameter. On the basis of this rate constant value it can be concluded that test chemical is biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Experimental data and Predicted data studies for the target compound3-octanol (CAS no. 589-98-0)and experimental studies for its structurally similar read across substance were reviewed for the biodegradation end point and their results are summarized as below.
First study was an experimental study reviewed from chemosphere journal (1979) in this study biodegradation experiment was conducted to determine biodegradation rate constant of test chemical 3-octanol (CAS no. 589-98-0) in this experiment activated sludge was obtained at the end of an aeration period from the semi-continuous culture maintained with peptone-glucose synthetic waste in the laboratory. After washing with a M/50 phosphate buffer (pH 7) it was used in the experiments. Following medium was used 81.5 mg of KH2P04, 196 mg of Na2HPO4, 10 mg of MgSO47H20 , 1.0 mg of FeSO47H20 , 10 mg of urea, 2.0 m% of ethanol, and water in 200 mL Erlenmeyer flask concentration of test chemical used was 0.05 ml/L. Then test material was anlyzed by gas chromatography. Biodegradation rate constant of test chemical 3-Octanol was determined to be 905 per hrs by using activated sludge as inoculums and test material analysis by GC as parameter. On the basis of this rate constant value it can be concluded that test chemical is biodegradable.
Next study was predicted data study done by using Estimation Programs Interface Suite (EPI suite, 2018) to estimate the biodegradation potential of the test compound 3-Octanol (CAS no. 598 -89 -0) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3-Octanol is expected to be readily biodegradable.
In another predicted data study biodegradability of test chemical 3-Octanol (CAS no. 589-98-0) was estimated by using OECD QSAR tool box v3.3 by considering seven closest read across chemical with molecular weight as primary descriptor. Percent biodegradation of the test chemical 3-Octanol was estimated to be 83.07 % by considering BOD as parameter and Microorganism as inoculum in 28 days. On the basis of percent degradability value it can be concluded that test chemical 3-Octanol is readily biodegradable.
Next study was experimental study done from authoritative database (J check, 2018) in this study the Biodegradation experiment was carried out of structurally similar read across chemical 2-Octanol (CAS no. 123-96-6) by taking activated sludge as inoculums at 30 mg/L concentration for 14 days. Biodegradation was analyzed by using three parameters that are BOD, TOC removal and test material analysis by GC. The initial concentration of read across chemical was 100 mg/L. After 2 weeks of incubation percent biodegradation of read across chemical 2-Octanol was observed to be 76 % by O2 consumption (BOD) parameter 96 % by TOC removal parameter and 100% degradation by test material analysis by GC parameter in 14 days. Therefore it is concluded that read across chemical 2-Octanol is readily biodegradable.
Last study was also experimental study done from authoritative database (J check, 2018) in this study the Biodegradation experiment was carried out of read across chemical 2-Ethylhexyl alcohol (CAS no. 104-76-7) by taking activated sludge as inoculums at 30 mg/L concentration for 14 days. Biodegradation was analyzed by using three parameters that are BOD, TOC removal and test material analysis by GC. The initial concentration of read across chemical was 100 mg/L. After 2 weeks of incubation percent biodegradation of read across chemical 2-Ethylhexyl alcohol was observed to be 89.5 % by O2 consumption (BOD) parameter and 100 % by both TOC removal parameter and test material analysis by GC parameter in 14 days. Therefore it is concluded that chemical 2-Ethylhexyl alcohol is readily biodegradable.
On the basis of results of above mentioned studies for target chemical 3-octanol (CAS no. 589-98-0)(from Chemosphere journal, OECD QSAR tool boxv3.3 and EPI suite) and supporting weight of evidence study (from J Check, 2018). It is concluded that the test chemical 3-octanol (CAS no. 589-98-0)can be expected to be readily biodegradable.
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