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EC number: 218-528-7 | CAS number: 2173-56-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30. Jun. 2016 to 20. Oct. 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- The test substance may interact with the endocrine system of humans and cause damage.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Genetically modified yeast (Saccharomyces cerevisiae) cultures can interact with the human estrogen or andregen receptors hERa and hAR and a plasmid containing a reporte gene (lacZ, encoding ß-galactosidase) and estrogen (YES) or androgen (YAS) responsive elements. Upon binding of a ligand, the hERa and hAR interact with the corresponding response element on the expression plasmid, leading to secretion of ß-galactosidase, which converts a yellow dyestoff into a red product. The red colour (red-ß-galactopyranoside) can be quantified by colorimetry at 570 nm. The measured OD570 correlates derictly with the activity of the substance which binds to the corresponding receptor.
The XeoScreen XL YES/YAS Assay system can indentify both activating (agonistic) and inhibitory (antagonistic) activities of the test substance. For the determination of the antagonistic activities, the samples are incubated with a fixed concentration of a reference agonist (17-ß estradiol for YES or 5a-dihydrotestosterone for YAS). Inhibition of the response relative to the fixed agonist concentration is a sign of antagonistic activity. - GLP compliance:
- yes (incl. QA statement)
- Remarks:
- certified by Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Str. 7, D-55116 Mainz, Germany
- Type of method:
- in vitro
- Remarks:
- genetically modified Saccharomyces cerevisiae used
Test material
- Reference substance name:
- Pentyl valerate
- EC Number:
- 218-528-7
- EC Name:
- Pentyl valerate
- Cas Number:
- 2173-56-0
- Molecular formula:
- C10H20O2
- IUPAC Name:
- pentyl valerate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: Yeast (Saccharomyces cerevisae)
- Strain:
- other: Yeast, genetically modified with human genes
- Remarks:
- hERa and hAR receptor, Expression plasmid carrying response elements and reporter gene lacZ
- Details on test animals or test system and environmental conditions:
- Saccharomyces cerevisiae (yeast) was grown in test vessels. All yeast cultures, media, chemicals and solutions necessary for this assay were included in the YES YAS Assay KIt. All solutions and media were obtained sterilized and at highest quality grade from Xenometrix AG, Gewerbestraße 25, CH-4123 Allschwil, Switzerland.
Administration / exposure
- Route of administration:
- other:
- Duration of treatment / exposure:
- 47.5h (YES), 51.5h (YAS) at 32^C with agitation (100rpm)
- Frequency of treatment:
- once
- Duration of test:
- 3 days before test, ca. 3 days during test
Doses / concentrations
- Remarks:
- 8 different concentrations between 3.16 * 10^-8 and 1 * 10^-4 mol/L
- Control animals:
- yes
- Details on study design:
- The yeast cultures were prapared 3 days before the experiment. On the day of the assay, the cultures were checked for growth with a microplate reader. Then the plates were prepared according to the XenoScreen kit: There are YES Agonist, YAS Agonist, Yes Antagonist and YAS Antagonist plates. For each sort of plates 8 different concentrations of the test substance or positive controls were added in duplicate. After ca. 50h the absorption values at 570nm (for detection of the ß-galactosidase activity and therefore agonistic or antagonistic activity of the test substance) and at 690nm (for cell density and therefore cell growth) were taken by a microplate reader. Then growth factor, ß-galactosidase activity and induction rate are calculated and dose response curves were drawn. A dilution of a test substance is considered to have an agonistic effect if the induction rate is =10 and a possible antagonistic effect if the induction rate is = 50, respectively.
- Statistics:
- not made
Results and discussion
Effect levels
- Key result
- Basis for effect level:
- other:
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- No endocrine activity observed in this test system.
Applicant's summary and conclusion
- Conclusions:
- No adverse effects on the endocrine system were detected in this test system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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