Registration Dossier
Registration Dossier
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EC number: 229-713-7 | CAS number: 6674-22-2
Endpoint summary
Administrative data
Description of key information
In the rat reproduction toxicity study, DBU was administered for 29 days to male rats and for 43 to 57 days to female rats. Doses of 150 mg / kg body weight have caused the appearance of parental toxicity, with macroscopic effects such as dark red stools and irregular stomach surface. Microscopic analysis showed hemorrhage, degeneration of the glandular mucosa, inflammation, hyperplasia, and hyperkeratosis. All effects were local and limited to the stomach, and can be attributed to the strong alkaline corrosiveness of the DBU. No other toxicologically significant change was observed in animals treated with 150 mg / kg body weight of DBU, whereas no adverse effects were found for the remaining dosages. The NOAEL for parental toxicity was then set at 50 mg / kg of body weight.
Key value for chemical safety assessment
Additional information
Bibliographic source:
REACH Registration Dossier, 1,8-diazabicyclo[5.4.0]undec-7-ene
Justification for classification or non-classification
All effects were local and limited to the stomach, and can be attributed to the strong alkaline corrosiveness of the DBU. No other toxicologically significant change was observed in the treated animals.
No classification is proposed based on available data.
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