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EC number: 235-310-7 | CAS number: 12163-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Aquatic toxicity studies with magnesium diniobate are not available, thus aquatic toxicity will be addressed with existing data on the dissociation products, i.e. magnesium and niobium ions.
Magnesium: Magnesium as an essential element has a very low potential for toxicity to freshwater and saltwater organisms.
Niobium: displays a very low mobility under all but the most extreme environmental conditions due to the high stability and very low solubility of niobium oxides. Thus, reported
Magnesium diniobate: The solubility of magnesium diniobate (MgNb2O6) in environmental media is expected to be low since dissolution in water resulted in Mg concentrations < 25 microg/L and Nb concentrations < 0.2 microg/L after 34 days. Aquatic toxicity is unlikely to occur since the substance is highly insoluble in water. Aquatic toxicity is also unlikely to occur since reported EC/LC50 values for short-term toxicity to algae, daphnia and microorganisms of niobium and short-term toxicity to algae, daphnia, fish and microorganisms of magnesium are at least 100-fold above the respective magnesium and niobium concentrations measured after dissolution in water for 34 days.
Additional information
Magnesium essentiality
The inorganic mineral elements are classified into two groups, the macro (major; > 1 g/L) and micro (trace; < 1 g/L [Soetan et al. 2010]) elements. The macro element magnesium, which is the most abundant divalent cation within living cells[Smith & Maguire, 1998], is essential to living organisms since it is an essential component of bones(including crustacean exoskeletons)and cartilage and an important activator of many key enzyme systems including kinases, (i.e. transfer of the terminal phosphate of ATP to sugar or other acceptors), mutases (transphosphorylation reactions), muscle ATPases and the enzymes cholinesterase, alkaline phosphatase, enolase, isocitric dehydrogenase, arginase, deoxyribonuclease and glutaminase. Moreover, Mg stimulates muscle and nerve irritability (contraction),is involved in the acid-base balance (pH regulation)and plays an important role in carbohydrate, protein and lipid metabolism[Tacon, 1987].Magnesium deficiency causes characteristic syndromes, reflecting its specific functions in the metabolism of animal or plants [Soetan et al. 2010].In general, Mg is readily absorbed through the gastro-intestinal tract (also gills of aquatic organisms) and transported in the blood plasma either in ionic form or bound to plasma proteins. Most of the Mg is stored primarily in bone (e.g. ~60 % for common carp [ADCP, 1978]), but also in muscle and extracellular fluids [Tacon, 1987]. The process of Mg homeostasis prevents any bioaccumulation [OECD SIDS, 2011] even at extremely high concentrations that may harm the organism. Finally, Mg can be excreted via urine (main route of excretion) and feces, but also via breast feeding (mammals) [OECD SIDS, 2011] or via the gills (fish), although the latter one has been shown to be rather limited [ADCP, 1978].
Mineral requirements as well as mineral functions are species-specificand are addressed in the respective endpoint summary of this dossier. It should further be kept in mind that minerals mutually interact affecting concentration and function of each single mineral [Soetan et al. 2010].
Reference
ADCP/REP/80/11 - Fish Feed Technology - Lectures presented at the FAO/UNDP Training Course in Fish Feed Technology, held at the College of Fisheries, University of Washington, Seattle, Washington, U.S.A., 9 October-15 December 1978.
OECD HPV Chemical Programme (2011), SIDS Initial Assessment Report for SIAM 32, National Institute of Environmental Research in Korea, Paris, France, p. 20.
Soetan, K.O., Olaiya, C.O., Oyewole, O.E., 2010. The importance of mineral elements for humans, Domestic animals and plants: a review. Afr. J. Food Sci. 4(5), 200–22.
Smith, R.L., and Maguire, M.E. (1998). Microbial magnesium transport: Unusual transporters searching for identity. Mol. Microbiol. 28(2), 217–226.
Tacon, A.G.I., 1987. The nutrition and feeding of farm fish and shrimp a training manual. 1. The essential nutrients. FAO Brasilia Brazil, GCP/RLA/075/ITA Field Document 2/E, p. 117.
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