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EC number: 248-983-7 | CAS number: 28348-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute oral toxicity of Na cumene sulfonate 0019
- Author:
- Huels AG,
- Year:
- 1 982
- Bibliographic source:
- Huels AG, Marl, Germany.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium cumenesulphonate
- EC Number:
- 248-983-7
- EC Name:
- Sodium cumenesulphonate
- Cas Number:
- 28348-53-0
- Molecular formula:
- C9H12O3S.Na
- IUPAC Name:
- sodium cumenesulphonate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- CAS Number: 28348-53-0
Identity: Cumene sulfonic acid, sodium salt
Purity: 96.0%
Remarks: Substance tested is a granular solid
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: not mentioned
- Weight at study initiation: 141 g (males); 117 g (females), mean weights
- Fasting period before study: 16 hours
- Housing: 1 - 5 animals in Makrolon cages, type III
- Diet (e.g. ad libitum): R10 Complete feed for rats ad libitum, supplied by Ssniff Spezialfutter GmbH, Soest, Germany
- Water (e.g. ad libitum): Drinking water ad libitum
- Acclimation period: 4 - 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 60 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- feeding ad libitum (food was withheld 16 hours prior to dosing).
- Doses:
- Single oral administration of 7000 mg/kg bw (vehicle water); no controls;
feeding ad libitum (food was withheld 16 hours prior to dosing). - No. of animals per sex per dose:
- 5/sex/dose group
- Control animals:
- no
- Details on study design:
- Observations:
• Mortality/clinical signs continuously for 6 hours on day 1 and daily until day 14.
• Body weights on day 1, 7 and 14.
• Necropsy on day 14 (3/sex/dose group).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- male: 0/5
female 2/5 - Clinical signs:
- One hour after application piloerection, slight ataxia, lateral position and increased water intake was noted. After 24 hours the surviving animals were free of symptoms.
- Body weight:
- No effects.
- Gross pathology:
- Post mortem reddening of the gastric mucosa was observed, the surviving animals showed no pathological changes in organs at necropsy.
Any other information on results incl. tables
Value: Oral LD50 >7000 mg/kg bw
Dose [mg/kg bw] effect |
|
7000 |
DR |
|||
Sex |
Day |
M |
F |
M |
F |
|
Mortality |
1-14 |
0/5 |
2/5 |
|
|
|
Clinical signs(A) |
1-14 |
+ |
+ |
|
|
|
Body weight |
1-14 |
No treatment related effects |
|
|
||
Necropsy(B) |
14 |
|
+ |
|
|
|
(A)Clinical observations included increased piloerection, ataxia, lateral recumbency and
increased water intake (lasting 24 hours after dosing).
(B)In the animals that died redness of the stomach mucosa was observed.
DR is dose related. (delete this column and line; it’s not dose related since there was only
one dose.)
Applicant's summary and conclusion
- Interpretation of results:
- other: practically nontoxic
- Conclusions:
- The acute oral LD50 in male/female rats is > 7000 mg/kg bw. No significant gross abnormalities were seen at autopsy.
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