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EC number: 233-031-5 | CAS number: 10024-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 April 1984 to 14 April 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 April 1984 to 10 May 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot No.of test material: 83040 - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 kg ± 200 g
- Housing: individually housed in polystyrene cages (540 x 360 x 315 mm) with a perforated polystyrene floor
- Diet: 150 g per rabbit per day
- Water: ad libitum
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20 ± 3°C
- Humidity: 30 to 70%
- Air changes: 12 to 14 times per hour
- Photoperiod: 12 hours lighting per day, 7.30 am to 7.30 pm - Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- The eyelids were held together for ten seconds to avoid any loss of test material. The animals were then restrained for one hour.
- Observation period (in vivo):
- 1, 24, 48 and 72 hours and 7, 14 and 21 days after instillation
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Any animals showing possible ocular lesions were eliminated from the study. 100 mg of the test material was placed into the conjunctival sac of the right eye of the animal, the upper and lower eyelids are held together for ten seconds to avoid the loss of any test material. The left eye served as a control. Each animal was immobilised in a plastic restraining box during treatment and for one hour afterwards.
Animals were immobilised for examination, the examinations were always carried out under the same conditions (especially lighting) and the treated eye was compared to the control at 1, 24, 48 and 72 hours post treatment and again at 7, 14 and 21 days after treatment
Observations of the cornea was made with the aid of a Heine's ophthalmoscope which was also used to observe the iris, pupil and lens, if required. If further examination was necesarry a slit lamp was used.
Observations were made on the following: conjunctivae (oedema and redness), pupil, iris congestion, corneal lesions and opacity degree. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.28
- Max. score:
- 3
- Reversibility:
- not fully reversible within:
- Remarks:
- 21 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within:
- Remarks:
- 21 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within:
- Remarks:
- 21 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within:
- Remarks:
- 21 days
- Interpretation of results:
- other: Irreversible effects on the eye (Category 1) in accordance with EU criteria
- Conclusions:
- Under the conditions of the study the test material requires classification for irreversible effects on the eye (Category 1).
- Executive summary:
The potential of the test material to cause irritation to the eye was determined in accordance with the standardised guideline OECD 405 using an in-vivo method.
Six male New Zealand White rabbits were treated with the test material which was placed into the conjunctival sac of the right eye of the animal, the upper and lower eyelids are held together for ten seconds to avoid the loss of any test material. The left eye served as a control. The eye was observed at 1, 24, 48 and 72 hours and at days 7, 14 and 21 for signs of ocular irritation.
Chemosis and conjunctival redness were observed in the treated eyes of all animals from 1 hour post-treatment and the effects were not reversible within the 21-day observation period. Iridial effects (score 1) were noted in all animals at all timepoints. Corneal opacity was observed in the treated eyes of all animals from 24 hours post-treatment and the effects were not reversible within the 21-day observation period.
Therefore, under the conditions of the study the test material requires classification for irreversible effects on the eye (Category 1).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Neodymium trichloride
- EC Number:
- 233-031-5
- EC Name:
- Neodymium trichloride
- Cas Number:
- 10024-93-8
- Molecular formula:
- Cl3Nd
- IUPAC Name:
- neodymium trichloride
- Test material form:
- solid
- Details on test material:
- - Appearance: Red
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot No.of test material: 83040
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 kg ± 200 g
- Housing: individually housed in polystyrene cages (540 x 360 x 315 mm) with a perforated polystyrene floor
- Diet: 150 g per rabbit per day
- Water: ad libitum
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20 ± 3°C
- Humidity: 30 to 70%
- Air changes: 12 to 14 times per hour
- Photoperiod: 12 hours lighting per day, 7.30 am to 7.30 pm
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after removal of the patch
- Number of animals:
- 6
- Details on study design:
- METHOD
The day before the application of the test material, the backs and flanks of six rabbits were clipped free of fur with an electric clipper, to expose a surface of 14 x 14 cm. Only animals with perfectly healthy intact skin showing no macroscopic sign of irritation, after a rest period of 24 hours were used for the study.
0.5 g of the test material was moistened with water and applied directly onto the animal skin and spread evenly over an area of ca. 6 cm² and then covered with a gauze pad about 2.5 cm².
The test material and gauze pad were held in contact with the skin with a semi-occlusive patch: 10 cm wide adhesive perforated tape applied on a crimped gauze bandage covering the whole clipped surface and wrapped around the animal.
The test material was kept in contact with the skin for 4 hours whilst the animals were kept in plastic restraining boxes.
After the exposure treatment the bandages were removed and if necessary any excess test material wiped from the skin with a gauze pad moistened with deionised water.
The cutaneous irritation was evaluated 1, 24, 48 and 72 hours after removal of the test material.
DESCRIPTION OF REACTIONS
Erythema and Eschar formation:
0 = No erythema
1 = Very slight erythema (barely perceptible)
2 = Well defined erythema
3 = Moderate to severe erythema
4 = Severe erythema (beet redness) to slight eschar formation (injuries in depth)
Oedema formation:
0 = No oedema
1 = Very slight oedema (barely perceptible)
2 = Slight oedema (edges of area well defined by definite raising)
3 = Moderate oedema (edges raised approximately 1 mm)
4 = Severe oedema (raised more than 1 mm and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Max. score:
- 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Very slight erythema was noted in one of the six treated animals at 1, 24, 48 and 72 hours following removal of the test material.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU criteria
- Conclusions:
- Under the conditions of this study the test material was determined to be non-irritating to the skin.
- Executive summary:
The potential of the test material to cause irritation to the skin was determined in accordance with the standardised guideline OECD 404 using an in-vivo method.
During the study, six male New Zealand White rabbits were treated with the test material under a semi-occlusive dressing for four hours. After the removal of the test material the skin was observed at 1, 24, 48 and 72 hours for cutaneous irritation.
Very slight erythema was observed in 1 out of 6 animals but no oedema was observed.
Under the conditions of this study the test material was determined to be non-irritating to the skin.
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