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EC number: 230-089-3 | CAS number: 6940-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1-bromo-4-chlorobutane
- EC Number:
- 230-089-3
- EC Name:
- 1-bromo-4-chlorobutane
- Cas Number:
- 6940-78-9
- Molecular formula:
- C4H8BrCl
- IUPAC Name:
- 1-bromo-4-chlorobutane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Purity 99.6%
Lot No. 917
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sprague-Dawley
- Females (if applicable) nulliparous and non-pregnant: [yes/no] no information
- Age at study initiation: five weeks old
- Weight at study initiation: 106 - 139 g for female, 100 - 132 g for male
- Fasting period before study: 18 hours
- Housing: 54 x 33 x 20 cm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period:at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 °C (18 - 25 °C)
- Humidity (%): 55 % (40 - 70 %)
- Air changes (per hr): 15 complete air changes per hours without re-circulation.
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: From: To: from one to fifteen
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 ml/kg - Doses:
- Preliminary study :400 mg/kg, 800 mg/kg, 2000 mg/kg
Main study : 800 mg/kg, 1265 mg/kg, 2000 mg/kg, 3162 mg/kg - No. of animals per sex per dose:
- Preliminary study: one male and one female rat per dose group
Main study: five male and five female rats per dose group - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Frequency of observation: The first hour after dosing and two further inspection during the remainder of Day 1. From Day 2 onwards, inspected twice a day.
The body weight Recorded on the day before dosing and on Days 1, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:none - Statistics:
- Probit analysis by the method of Finney (1971) was used to determine the acute median lethal dosage, 95% confidence interval and slope of the dose response curve of the test material for both sexes, The calculations were performed by the GLIM statistics program (Baker and Nelder, 1978) using a special macro program developed by Baker (Baker, 1980)
Results and discussion
- Preliminary study:
- Dosage (mg/kg) Mortality
Male Female
400 0/1 0/1
800 0/1 0/1
2000 1/1 0/1
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 591 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 160 - <= 2 021
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 167 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 354 - <= 2 981
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Remarks:
- combined
- Effect level:
- 1 885 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 542 - <= 2 228
- Mortality:
- Animals died at dosages of 1265 mg/kg or above. The deaths occurred during the first over-night period and on the second and fourth days after dosing
- Clinical signs:
- Ante mortem signs comprised lethargy, decreased motor activity, prone position, staggering gait, muscle tremor, bradypnoea, tachypnoea, hyperpnoea, hypopnoea, cold to touch, pigmented staining of the snout, piloerection, ungroomed apprearance, thin body conformation, salivation, hunched posture, closed eyes, pigmented and serous orbital secretion and reddening.
Sign of reaction to treatment in the surviving animals comprised irritability, lethargy, staggering gait, decreased motor activity, cold to the touch, piroerection, salivation, hunched posture, eyes, serous orbital discharge and reddening The animas were overtly normal six days after treatment. - Body weight:
- The surviving animals achieved expected body weight gains.
- Gross pathology:
- Necropsy of the decendents revealed low incidences or single cases of abnormal stomack contents, dark areas on the stomach glandular mucosa, pale cranial fur staining, hairloss on cervical dorsum, pale areas on the liver, large liver and pale kidneys.
Necropsy of the surviving animals revealed pale areas on the liver with interlobular adhesions, abnormal gastro-intestinal contents, dark sub-mandibular and mandibular lymph nodes and testicular masses amongst two males and distended uterus in two females
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of this study the acute oral median lethal dosage (LD50) were 1591 mg/kg for male, 2167 mg/kg for female and 1885 mg/kg as combined. Accordingly, TMCB was assigned to the class 'slight oral toxicity.
- Executive summary:
Under the conditions of this study the acute oral median lethal dosage (LD50) were 1591 mg/kg for male, 2167 mg/kg for female and 1885 mg/kg as combined. Accordingly, TMCB was assigned to the class 'slight oral toxicity.
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