Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-667-0 | CAS number: 9003-98-9
Endpoint summary
Administrative data
Description of key information
Deoxyribonuclease was tested for acute toxicity, including read-across studies.
Fish: Deoxyribonuclease as not tested, however, Alpha-amylase was not toxic at the the tested concentration of 100 mg/L (58.3 mg aep/L) and thus the NOEC was determined to be 100 mg/L (58.3 mg aep/L). The LC50 value could not be determnined due to the absence of toxicity of the test compound at the tested concentration. Due to the similar nature of enzymes, similar results can be expected for the test substance deoxyribonuclease.
Daphnia magna: Exposure of freshwater invertebrate Daphnia magna to the test item has been investigated and gave the following results based on the geometric mean measured test concentrations:
EC50 = 1546 (932 – 2571) mg enzyme concentrate dry matter/L, equivalent to 214 mg active enzyme protein (aep)/L (analytically measured as aep).
NOEC = 852 mg enzyme concentrate dry matter/L.
LOEC = 1704 mg enzyme concentrate dry matter/L.
Algae: Exposure of Raphidocelis subcapitata to the test item gave the following results based on the geometric mean measured test concentrations:
EC50 = 59 (26 – 108) mg enzyme concentrate dry matter/L, equivalent to 8.1 mg active enzyme protein (aep)/L (analytically measured as aep).
NOEC = <5.3 mg enzyme concentrate dry matter/L.
LOEC = ≤5.3 mg enzyme concentrate dry matter/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
