Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-969-4 | CAS number: 90-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- 1-Naphthol – Single and Repeated Dose (30-Day) Oral Toxicity Studies In The Mouse
- Author:
- Poole, A., and Buckley, P.
- Year:
- 1 989
- Bibliographic source:
- Food and Chemical Toxicity, 27, 233-238
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- - Principle of test: Standard acute method
- Short description of test conditions: Four mice (2/sex) were exposed to 1-naphthol at doses of 500, 1000 and 2000 mg/kg bw in propane-1,2-diol by gavage. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-naphthol
- EC Number:
- 201-969-4
- EC Name:
- 1-naphthol
- Cas Number:
- 90-15-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- naphthalen-1-ol
- Test material form:
- solid
- Details on test material:
- No data
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: No data
- Expiration date of the lot/batch:No data
- Purity test date: No data
- Purity : no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: No data
- Stability under test conditions: No data
- Solubility and stability of the test substance in the solvent/vehicle: No data
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING No
FORM AS APPLIED IN THE TEST : Suspension
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Remarks:
- Cr1: CD-1 (ICR)BR)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK limited
- Age at study initiation: 6-7 weeks old
- Weight at study initiation: No data
- Housing: solid-bottomed cages
- Diet (ad libitum): Porton rat Diet Pellets (Labsure Animal Food Ltd. Poole, Dorset)
- Water (ad libitum): filtred tap-water
- Acclimation period: yes - 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 22°C
- Humidity (%): 40-60%
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12h light/ 12h black
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: propane-1,2-diol-water (1:1 v/v)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1/1
- Amount of vehicle (if gavage): 10 ml/kgbw
- Justification for choice of vehicle: No data
- Lot/batch no. (if required): No data
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kgbw - Doses:
- 500, 1 000 and 2 000 mg/kgbw
- No. of animals per sex per dose:
- 2 per sex per dose
- Control animals:
- yes
- Remarks:
- one untreated and one with the vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: yes (colon, duodenum, gall bladder, heart, ileumn kidneys, liver, lungs, parathyroid, gland, stomach (forestomach and glandular region) and thyroid gland
- Other examinations performed: clinical signs, body weight,, clinical chemistry (ALT, ALP, GLDH, TP, ALB, BUN, CREA, GLU) and heamatology analyses (Hgb, RBC, Hct, Plt, WBC) - Statistics:
- From the heamatology and clinical chemistry data generated in these studies, arithmetic means and standard deviations were calculated.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The mice dosed at 2000 mg/kgbw became subdued shortly after treatment developed abnormal respiration and tremors and finally suffered total collapse. All of the animals in this dose group were killed in extremis between 15 and 90 min after dosing.
One male in the low-dose (500 mg/kgbw) group was killed in extremis approximately 2 hours after dosing. - Clinical signs:
- other: The animals treated at 1000 mg/kgbw also showed subdued behaviour with piloerection, but recovered for the signs. The other animals in the 500 mg/kgbw group, although showing subdued behaviour, laboured respiration and piloerection, recovered to survive t
- Gross pathology:
- No data
- Other findings:
- - Histopathology:
Renal changes (1) eosinophilic deposits in the lumen of the distal tubules and collecting ducts associated with degeneration of the distal tubular epithelia were seen in the 3 male mice killed at 2000 mg/kgbw and 1 to 500 mg/kgbw. and 1 female mice dosed at 1000 mg/kgbw (both of which survived) (2) papillary necrosis with an associated intravascular thrombosis in one male and both female mice receiving 1000 mg/kgbw and (3) marked dilatation of both corical and medullary tubules in both female mice dosed at 1000 mg/kgbw.
Gastric changes consisted of lesions in the forestomach and glandular region. These changes are seen in all but one of the mice dosed at 1000 and 500 mg/kgbw, included focal splitting of the squamous epithelium which was generally associated with vascular congestion and an acute inflammatory cell infiltration. Sloughing of the superficial epithelium of the glandular mucosa was observed in all mice dosed at 2000 mg/kgbw, in one male and one female mouse receiving 500 mg/kgbw. Generally, this change was associated with vascular congestion and an acute inflammatory cell inflitration.
- Potential target Organs : No data
- Other observations: no differences in the haematology or clinical chemistry data obtained from the control goup and those dosed with naphthol.
Applicant's summary and conclusion
- Interpretation of results:
- other: study not considered for classification, but effect level is in line with harmonized Cat 4 classification
- Remarks:
- Note: substance has a harmonized classification as Cat 4
- Conclusions:
- The LD50 was estimated to be between 1000 to 2000 mg/kg bw.
- Executive summary:
Four mice (2/sex) were exposed to 1-naphthol at doses of 500, 1000 and 2000 mg/kg bw in propane-1,2-diol by gavage. One male in the 500 mg/kg bw group was killed in extremis two hours post dosage. Other animals in this group showed piloerection and laboured respiration. Animals in the 1000 mg/kg bw group showed piloerection, but survived to the end of the study. Shortly after dosing animals exposed to 2000 mg/kg bw showed abnormal respiration and soon after dosing collapsed. All animals in this dosage group were killed in extremis from 15 to 90 minutes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.