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EC number: 273-224-1 | CAS number: 68953-70-8 The complex combination of alkanolamines from the distillation of reaction products of ammonia and oxirane. It consists predominantly of triethanolamine, diethanolamine and higher amines from the reaction of triethanolamine and oxirane.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Since Amix TE (CAS 68953-70-8) is composed of at least 75 % of TEA (CAS 102-71-6) and the available data for AMIX TE are limited, a read-across to TEA was conducted. In addition to the genetic toxicity studies for TEA mentioned below, an Ames test with Amix TE was performed, using TA 1535, TA 1537, TA 98 and TA 100 at concentrations up to 5000 µg/plate with and without metabolic activation. Treatment with Amix TE was not associated with reverse mutations in any of the strains tested (BASF AG 40M0444/954218).
TEA was tested in the Ames reverse mutation assay using S. typhimurium strains TA 1535, TA 1537, TA 97, TA 98 and TA 100 at a concentration up to 10000 µg/plate with and without metabolic activation, performed according to Haworth et al. (Environ Mutagen 5, Suppl 1, 3 -142). Treatment with TEA was not associated with reverse mutations in any of the strains tested (Mortelmans, 1986). Induction of chromosomal aberrations and sister chromatid exchanges was investigated in Chinese hamster ovary cells, exposed to concentrations up to 10100 µg/mL (which induced cytotoxicity). All tests were negative in the absence as well as in the presence of metabolic activation (Galloway, 1987). An in vitro gene mutation assay in mammalian cells in not available yet, but a HPRT test will be performed by Dow. No reliable in vivo genotoxicity study is available, but will also not be necessary providing the HPRT test will be negative.
Short description of key information:
Since Amix TE (CAS 68953-70-8) is composed of at least 75 % of TEA (CAS 102-71-6) and the available data for AMIX TE are limited, a read-across to TEA was conducted.
In addition to the genetic toxicity studies for TEA, an Ames test with Amix TE was performed, indicating no reverse mutations in any of the strains tested (BASF AG 40M0444/954218). TEA did not cause gene mutations in Salmonella typhimurium (Ames test), nor were chromosomal aberrations or sister chromatid exchanges induced in Chinese hamster ovary cells. All tests were performed in the absence and presence of metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Amix TE does not need to be classified according to Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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