Registration Dossier
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EC number: 209-968-0 | CAS number: 599-64-4
Endpoint summary
Administrative data
Description of key information
Additional information
The aquatic toxicity of p-Cumylphenol was investigated on three trophic levels: algae, aquatic invertebrates, and fish.
A reliable algae growth inhibition test to OECD Guideline 201 was performed wth R. subcapitata at concentrations of p-Cumylphenol ranging from 0.3 to 17.5 mg/L for 72 hours under static conditions with continuous illumination. Under the conditions of this study, the 48 and 72 hour EC50, in respect to algal growth rate were 1.0 and 1.4 mg/L, respectively. The 48 and 72 hour NOEC were determined to be 0.5 and 0.9 mg/L.
An acute immobilization test was conducted with Daphnia magna according to OECD Guideline 202. Daphnia were exposed to concentrations of p-Cumylphenol ranging from <0.2 to 9.2 mg/L for 48 hours under static conditions with a 16/8 light/dark cycle. Under the conditions of this study, the EC50 concentrations at 24 and 48 hours were 1.6 mg/L and 0.9 mg/L, respectively. The NOECs at 24 and 48 hours were 1.1 mg/L and 0.6 mg/L, respectively. The LOECs at 24 and 48 hours were 2.2 mg/L and 1.1 mg/L, respectively.
An acute fish toxicity test was conducted with Oncorhynchus mykiss according to OECD Guideline 203. O. mykiss were exposed to concentrations of p-Cumylphenol ranging from <0.2 to 9.2 mg/L for 96 hours under static conditions. Under the conditions of this study, the LC50 for p-Cumylphenol exposure was determined to be 0.9 mg/L at 24, 48, 72 and 96 hours.
Although growth inhibition tests with algae would not trigger an acute toxicity classification (<1 mg/L), tests with invertebrates and fish report toxicities below this threshold and thus p-Cumylphenol warrants an acute aquatic toxicity classification. Further, coupled with the fact that p-Cumylphenol is not readily biodegradable, a chronic aquatic toxicity classification is also applicable.
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008, the substance requires classification with respect to aquatic toxicity as Acute Category 1 (H400: Very toxic to aquatic life) and Chronic Category 1 (H410: Very toxic to aquatic life with long lasting effects).
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