Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicic acid, calcium salt
- EC Number:
- 215-710-8
- EC Name:
- Silicic acid, calcium salt
- Cas Number:
- 1344-95-2
- IUPAC Name:
- Silicic acid, Calcium salt
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Synthetic amorphous silicas
- Analytical data after ignition: SiO2 (ca. 79 %); CaO (ca. 7%); NaCl (ca. 1.2 %)
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: direct addition and stirring (1000 mg/L) or as acetonic suspension (1 and 10 % silicate in solution, w/v) (see Report, Tab. I)
- Eluate: no, used as dispersion/suspension
- Differential loading: yes
- Controls: vehicle control not explicitly indicated to
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): acetone for 1, 10, and 100 mg/L
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s):
0.1 mL acetone/L at 1 and 10 mg silicate/L
1 mL acetone/L at 100 mg silicate/L
0 mL acetone/L at 1000 mg silicate/L
- Evidence of undissolved material (e.g. precipitate, surface film, etc): yes
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Source: no data
- Age at study initiation: no data (fingerlings)
- Length at study initiation: range 35 - 75 mm
- Weight at study initiation (mean and range, SD): no data
- Method of breeding: no data
- Feeding during test: no
ACCLIMATION
- Acclimation period: >= 14 d before testing, 24 h in test vessel before addition of the test material
- Acclimation conditions (same as test or not): yes
- Type and amount of food: Purina Trout Chow
- Feeding frequency: until 3 d prior to testing
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
Test conditions
- Test temperature:
- 13 °C (15 ± 2 °C)
- pH:
- control: 6.9 - 7.3;
tests: 7.2 - 7.3 (only measured in case of mortality) - Dissolved oxygen:
- control: 4.3 - 7.4 mg/L;
tests: 5.6 - 8.2 mg/L (only measured in case of mortality) - Nominal and measured concentrations:
- 0, 1, 10, 100, and 1000 mg/L [ppm] (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, fill volume: Vessel lined with a disposable PE bags, 12.5 L
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): no data
- Biomass loading rate: no data
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water prepared from deionized water
30 mg CaSO4/L; 30 mg MgSO4/L; 48 mg NaHCO3/L; 2 mg KCl/L
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality and behaviour
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
-
- Justification for using less concentrations than requested by guideline:
- Range finding study: done
- Test concentrations: no data
- Results used to determine the conditions for the definitive study: no data - Reference substance (positive control):
- yes
- Remarks:
- Toxaphene
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: at 1 - 100 mg/L, no particular findings
at 1000 mg/L, quiescent behaviour
- Observations on body length and weight: no data
- Other biological observations: none
- Mortality of control: none
- Other adverse effects control: none
- Abnormal responses: at 1000 mg/L
- Effect concentrations exceeding solubility of substance in test medium: yes - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Mortality: 0.01 0.018 0.056 mg/L
===================
1/10 3/10 10/10
----------------------------
- LC50(96 h): 0.023 mg/L - Reported statistics and error estimates:
- LD50 determined according to Litchfield and Wilcoxon 1949
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Mortality under test conditions: Calcium silicate (data taken and derived from Report, Tab. I):
Concentration
Mortality
(nominal, mg/L)
%*
24 h
48 h
72 h
96 h
Control
-
0/10
0/10
0/10
0/10
1
1
0/10
0/10
0/10
0/10
10
10
0/10
0/10
0/10
0/10
100
10
0/10
0/10
1/10
1/10
1000
100
0/10
1/10
1/10
2/10
* The silicate was dispensed into the test vessel in undiluted form or as a 1% or 10% (w/v) solution in acetone.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.