Registration Dossier
Registration Dossier
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EC number: 234-719-8 | CAS number: 12027-38-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Toxtree (Estimation of Toxic Hazard - a Decision Tree Approach) v. 2.6.6 Software for estimation of toxic hazard by applying a decision tree approach Ideaconsult Ltd
- Author:
- Ideaconsult
- Year:
- 2 016
- Bibliographic source:
- http://toxtree.sourceforge.net
Materials and methods
- Principles of method if other than guideline:
- QSAR method
Test material
- Reference substance name:
- 12-wolframosilicic acid
- EC Number:
- 234-719-8
- EC Name:
- 12-wolframosilicic acid
- Cas Number:
- 12027-38-2
- Molecular formula:
- H.1/4O40SiW12
- IUPAC Name:
- tetrakis(hexaoxocyclotritungstoxane); silicic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- The model was run twice using the following two SMILES code structural formulas that are the substructures that comprise the substance known by this EC number:
[W]1(=O)(=O)O[W](=O)(=O)O[W](=O)(=O)O1
[Si](O)(O)(O)O
Test animals
- Species:
- other: rodent
Results and discussion
Test resultsopen allclose all
- Genotoxicity:
- negative
- Remarks on result:
- other: no alerts for structure [W]1(=O)(=O)O[W](=O)(=O)O[W](=O)(=O)O1
- Genotoxicity:
- negative
- Remarks on result:
- other: no alerts for structure [Si](O)(O)(O)O
Applicant's summary and conclusion
- Executive summary:
A valid QSAR model based on the Toxtree ISS rulebase of alerts for the in vitro mouse micronucleus assay predicted that the two substructures that comprise the substance produced no alerts for mutagenicity.
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