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EC number: 220-816-2 | CAS number: 2906-12-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial, non-adapted
- Details on inoculum:
- - Origin: activated sludge from BASF's wastewater treatment plant
- Adaptation: none - Duration of test (contact time):
- 25 d
- Initial conc.:
- 400 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Test performance:
- - pH was neutralized before test initiation
- pH before neutralization: 9.7
pH after neutralization: 5.7 - 7.9 - Parameter:
- % degradation (DOC removal)
- Value:
- > 70
- Sampling time:
- 25 d
- Details on results:
- - DOC elimination after 3 h (%): -1
- Degradation kinetics:
Time [d] Degradation [%]
1 -1
7 10
14 54
21 97
25 98 - Interpretation of results:
- inherently biodegradable
- Conclusions:
- The biodegradation of the test substance was >70% in a OECD 302 B Zahn-Wellens-Test. Thus, the test substance was inherently biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Deviations:
- yes
- Remarks:
- COD analyzer was out of order for 12 days.The D0 and D4 samples were analyzed after 12 and 8 days storage in the fridge instead of 7 days allowed by the guideline. The results were still consistent. This deviation is considered to have no impact.
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Inoculum came from a secondary effluent from a municipal wastewater treatment plant (Versailles, 78, France). The sample was centrifuged at 4000 g for 20 minutes at 20°C. The pellet was dissolved in the test medium so that the solids were concentrated 150 times compared to the initial sample. The concentration of bacteria in the test medium was 2 900 000 bacteria per mL.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 244.5 mg/L
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- The study followed the OECD 301A guideline. Eight flasks were used: two blanks, one control (sodium benzoate), two test item, one sterile, one for toxic inhibition and one for adsorption. Flasks were 500 mL capacity and filled with a volume of 250 mL. They were incubated at 22°C for 28 days. COD measurements occurred on days: 4, 7, 11, 14,18, 21, 25 and 28 (end of the study).
Before each sampling, water loss by evaporation were estimated by weighing the flasks. Water loss was compensated by adding quantity of ultra-pure water equivalent to the missing amount of water. Then, the flasks were shaken and sampled. - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- No preliminary study was conducted.
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 18
- Sampling time:
- 28 d
- Details on results:
- 3-isopropoxypropylamine biodegradation rate was low. Ultimate biodegradation reached only 18% after 28 days incubation. No significant adsorption was observed (<10%). The test item did not prove toxic to the inoculum. No abiotic ultimate biodegradation took place.
- Results with reference substance:
- Ultimate biodegradation of sodium benzoate was over 70% within 14 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- 3-isopropoxypropylamine is not readily biodegradable.
- Executive summary:
The aim of this study was to evaluate ready biodegradability of 3 -isopropoxypropylamine. The study followed the OECD 301A guideline. Eight flasks were used: two blanks, one control (sodium benzoate), two test item, one sterile, one for toxic inhibition and one for adsorption. Flasks were 500 mL capacity and filled with a volume of 250 mL. They were incubated at 22°C for 28 days. COD measurements occurred on days: 4, 7, 11, 14,18, 21, 25 and 28 (end of the study). Before each sampling, water loss by evaporation were estimated by weighing the flasks. Water loss was compensated by adding quantity of ultra-pure water equivalent to the missing amount of water. Then, the flasks were shaken and sampled. The samples were centrifuged at 20°C. Supernatants were acidified with hydrochloric acid, degazed with nitrogen for 5 minutes and then analysed for COD with a dedicated analyzer. 3-isopropoxypropylamine biodegradation rate was low. Ultimate biodegradation reached only 18% after 28 days incubation. No significant adsorption was observed (<10%). The test item did not prove toxic to the inoculum. No abiotic ultimate biodegradation took place.
In conclusion, the test is valid and according to this test, 3-isopropoxypropylamine is not readily biodegradable.
Referenceopen allclose all
Description of key information
The substance is not readily biodegradable according to an OECD 301A test. The substance is however inherently biodegradable according to an OECD 302 test.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
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