Registration Dossier
Registration Dossier
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EC number: 208-293-9 | CAS number: 520-45-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Dehydroacetic acid (DHA): 1. Acute and chronic toxicity
- Author:
- Spencer HC, Rowe VK & McCollister DD
- Year:
- 1 950
- Bibliographic source:
- J. Pharmacol. Exp. Therap., 99; 57-68
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- - Principle of test: Patch test
- Parameters observed: skin reaction after application of the test substance - GLP compliance:
- no
Test material
- Reference substance name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- EC Number:
- 208-293-9
- EC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- Cas Number:
- 520-45-6
- Molecular formula:
- C8H8O4
- IUPAC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- no
- Subjects:
- - Number of subjects exposed: 200
- Sex: 100 females, 100 males - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Vehicle / solvent: water
- Concentrations: 65% (w/v)
- Volume applied: impregnated
EXAMINATIONS
- Other: visual observation
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 200
- Number of subjects with irritating reactions: 0
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
