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EC number: 215-350-1 | CAS number: 1323-03-1
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- chronic exposure
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- 1. SOFTWARE: OECD QSAR TOOLBOX
2. MODEL (incl. version number): ECOSAR v1.1 Class-specific Estimations
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: O=C(OCCCCC[CC]CC]CCCCCCC)C(O)C
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Fish - Chronic Value (ChV) = 10^([log (LOEC x NOEC)]/2)
- Class Specific LogKow Cut-Offs: If the log Kow of the chemical is greater than the endpoint specific cut-offs presented below, then no effects at saturation are expected for those endpoints.
Esters: Maximum LogKow: 8.0 (ChV)
Baseline Toxicity SAR Limitations: Maximum LogKow: 8.0 (ChV) - Principles of method if other than guideline:
- ECOSAR v1.1 Class-specific Estimations
- GLP compliance:
- no
- Analytical monitoring:
- not required
- Test organisms (species):
- not specified
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Remarks on exposure duration:
- ChV is a chronic value with undefined duration.
- Hardness:
- approximately 150 mg/L CaCO3, r
- Test temperature:
- abient
- pH:
- 7
- Dissolved oxygen:
- 100%
- Salinity:
- not applicable
- Conductivity:
- not specified
- Details on test conditions:
- The total organic carbon content should not exceed 2 mg/L
- Key result
- Dose descriptor:
- other: ChV
- Effect conc.:
- 0.01
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: sub-lethal effects
- Remarks on result:
- ChV (chronic value, QSAR)
- Remarks:
- Fresh water
- Key result
- Dose descriptor:
- other: ChV
- Effect conc.:
- 0.088 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: sub-lethal effects
- Remarks on result:
- ChV (chronic value, QSAR)
- Remarks:
- Seawater
Reference
Description of key information
Chronic value (ChV) calculated based on QSAR estimated individual ChV value for the C14 lactate being the main constituent.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.01 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 0.09 mg/L
Additional information
Since alkyl lactates are readily biodegradable, chronic exposure is not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
