1,4-naphthoquinone

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1993

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

review article or handbook

Title:

1,4-Naphthoquinone - BUA Report 211 (October 1998)

Author:

GDCh-Advisory Committee on Existing Chemicals (BUA)

Year:

1998

Bibliographic source:

S.Hirzel Verlag Stuttgart; Wissenschaftliche Verlags-Gesellschaft Stuttgart, 2000 , ISBN3-7776-1064-X

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

performed in 1981

GLP compliance:

yes

Test material

Test material information

1

Reference substance name:

1,4-naphthoquinone

EC Number:

204-977-6

EC Name:

1,4-naphthoquinone

Cas Number:

130-15-4

Molecular formula:

C10H6O2

IUPAC Name:

1,4-naphthoquinone

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Duration of exposure:

4 h

Results and discussion

Any other information on results incl. tables

The acute inhalation toxicity of 95.8% pure 1,4 -naphthoquinone was studied in accordance with OECD guideline No. 403. Groups of 5 male and 5 female Sprague Dawley rats (initial weight ca. 200 g) were exposed to 1,4 -naphthoquinone as a solid aerosol by inhalation at analytically determined concentrations of 0.065, 0.036 and 0.021 mg/l air for 4 hours (whole body exposure) with an observation period of 14 days The mean aerodvnamic particle diameter was 3.8 to 4.2 µm anel the respirable fraction <6 µm) was between 64.4 and 69.8%. During exposure, signs of irritation of the eyes and respiratory tract, which continued into the observation period, were seen in all concentration groups. Clouding of the cornea developed in 5/17 surviving animals in the intermediat and low concentration groups. Feed and water consumption was decreased for up to 7 and 5 days after exposure, respectively. Body weight declined for up to 5 days after exposure and the weight of the surviving rats did not reach that of the control animals again by the end of the observation period, except in the low concentration group. Post-mortems revealed congestion of the lungs, which were mottled in places, and histological examination showed vacuolisation and necrotic foci in the liver cells. The LC50 values were 0.039 mg/l in males, 0.053 mg/l in females and 0.046 mg/l for both sexes combined.

ormal respiration, reduction in food consumption and body weight, pale and mottled lungs, microscopic changes in lungs

(congestion), livers (hepatocyte vacuolisation, necrosis, congestion/dilatation) and kidneys (tubular basophilia, dilatation of tubular lumen).

Applicant's summary and conclusion

Interpretation of results:

Category 1 based on GHS criteria

Conclusions:

LC 50=0.046 mg/l