Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-636-9 | CAS number: 108-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US. 52 FR 42964, 49 CFR 173.136(a)
- Principles of method if other than guideline:
- Test material is applied to the shaved skin of rabbits for 3 min, 60 min and 4 hr, and then removed and the site is rinsed. Evaluations of the site are made at 30-60 min and 48 h after exposure. Skin erythema, edema and corrosion are assessed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methylpyridine
- EC Number:
- 203-636-9
- EC Name:
- 3-methylpyridine
- Cas Number:
- 108-99-6
- Molecular formula:
- C6H7N
- IUPAC Name:
- 3-methylpyridine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml/site, undiluted
- Duration of treatment / exposure:
- 3 min, 60 min and 4 h.
- Observation period:
- 30-60 min, and 48 h.
- Number of animals:
- 6 rabbits per group
- Details on study design:
- Corrosion is defined as irreversible alteration or destruction to the tissue in at least 3 of the animals. Necrosis is defined as ulceration or necrosis of the skin.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 3 min
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: no indication of corrosion
- Remarks:
- Corrosion study at 3 min, 60 min, 4 h
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 60 min
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: in 1 of 6 animals in this group
- Remarks:
- Qualitative scoring: presence/absence of ulceration/necrosis. Corrosion study at 3 m, 60 min and 4 h
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: in 3 of 6 animals
- Remarks:
- Qualitative scoring: presence/absence of ulceration/necrosis. Corrosion study at 3 m, 60 m and 4 h
Any other information on results incl. tables
No effects after a 3 minute exposure.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: other: U.S. Department of Transportation
- Conclusions:
- 3-Methylpyridine was tested for skin corrosion using U.S. Department of Transportation guidelines. The substance was corrosive to the skin of rabbits after a 4 h occlusive exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.