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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental Starting Date: 24 July 2015 Experimental Completion Date: 29 September 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
81 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
>= 11.5 - <= 11.7
Details on results:
Please see section Remarks on results including tables and figures.

Results

Preliminary Test

The preliminary estimate of water solubility was 82 g/L at 20.0 ± 0.5 °C.

Main Test

Please see Attachment 1 of this Summary for the Typical Chromatography.

The mean peak areas relating to the standard and sample solutions are shown in the following table:

 

Table 3.10

 

Solution

Mean Peak Area

Standard 540 mg/L

3.3793 x 106

Standard 657 mg/L

4.2134 x 106

Sample 1A

2.5434 x 106

Sample 1B

2.5720 x 106

Standard 540 mg/L

3.0661 x 106

Standard 657 mg/L

3.8168 x 106

Sample 2A

2.1529 x 106

Sample 2B

2.0374 x 106

Standard 540 mg/L

2.7529 x 106

Standard 657 mg/L

3.4204 x 106

Sample 3A

2.2247 x 106

Sample 3B

2.0460 x 106

Standard 551 mg/L

6.3321 x 105

Standard 515 mg/L

6.0458 x 105

Sample 4A

4.4757 x 105

Sample 4B

4.6184 x 105

 

The concentration (g/L) of test item in the sample solutions is shown in the following table:

 

Table 3.11

 

Sample Number

Time Shaken at

~ 30 ºC (hours)

Time Equilibrated at 20 ºC (hours)

Concentration (g/L)

Solution pH

1

24

94

80.7

11.7

2

48

96

82.3

11.7

3

72

96

82.9

11.7

4

24

24

78.3

11.5

 

Mean concentration:                        81.0 g/L at 20.0 ± 0.5 ºC
Range:                                               78.3 to 82.9 g/L

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 56 to 1.12 x 103mg/L. This was satisfactory with a correlation coefficient (r) of 0.9998.

 

Conclusions:
The water solubility of the test item at 20.0 ± 0.5 °C has been determined to be 81.0 g/L of solution.
Executive summary:

The determination was carried out using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

The test system consisted of purified (reverse osmosis) water with a resistivity of greater than 15MΩ.

Conclusion

The water solubility of the test item at 20.0 ± 0.5 °C has been determined to be 81.0 g/L of solution.

Description of key information

The water solubility of the test item at 20°C has been determined to be 81.0 g/L of solution.

Key value for chemical safety assessment

Water solubility:
81 g/L
at the temperature of:
20 °C

Additional information