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Diss Factsheets
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EC number: 946-260-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Category Approach for Primary alkyl amines and their salts e.g. Acetates
Primary alkyl amines and acetate salts are characterized by the hydrophobic aliphatic alkyl chain as well as a hydrophilic amine/ammonium group. They are mostly protonated under physiological or environmental conditions (pH 4-9). The degree of protonation is exclusively determined by the pKa and the ambient pH and therefore it is irrelevant if the amine itself or its salt is considered.
Considering these characteristics and that primary alkyl amines and primary alkyl amines acetates have a close structural relationship and share common functionalities as well as metabolic pathways, they can be considered as chemically and biologically equivalent. It is therefore imperative to use read-across principles in the assessment of primary alkyl amines and acetate salts.
Primary alkyl amines were already assessed for their environmental and human health hazards and risks under the EU Existing Chemicals Regulation 793/93/EEC. Industry has provided a justification for the category approach to the German rapporteur BAuA on 2001-04-07. This justification was accepted as basis for the EU Risk assessment and is used for the REACH registration as well.
Speciation of Primary alkyl amines
In aqueous medium the unprotonated and the protonated amine are in equilibrium. The percentage of the unprotonated and the protonated amine is determined by the acid constant pKa and the given pH. In the table the percentages are given as function of pH and the pKa of 10.6 for Primary alkyl amines.
pH | Percentage Protonated amine (N+) | Percentage Unprotonated amine (N) |
9 | 97.5% | 2.5% |
7 | 99.975% | 0.025% |
4 | 99.99997% | 0.00003% |
CONCLUSION:
Under environmental conditions (esp. high dilution and moderate pH) it is not relevant if the unprotonated or the protonated amine will be introduced in an aquatic medium. The composition of the protonated and unprotonated amine is solely determined by the pKa and the given pH (see table above). Therefore test results in aqueous media from the unprotonated and protonated amine are equivalent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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