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Diss Factsheets
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EC number: 203-951-1 | CAS number: 112-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was not conducted in accordance with GLP but sufficient data is available for the interpretation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C6H13OCH2CH2OH
- IUPAC Name:
- 2-hexyloxyethanol
- Details on test material:
- - Name of test material (as cited in study report): Hexyl CELLOSOLVE (Ethylene glycol monohexyl ether)
- Physical state: Clear, non-viscous liquid
- Lot/batch No.: S074565
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specified in the report
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Sealed 120 liter inhalation chamber
- Exposure chamber volume: 120 liter
- Source and rate of air: 2.5 lit/minute - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Remarks on duration:
- none
- Concentrations:
- Substantially saturated vapor, single exposure to rats: Static conditions at 26°C
- No. of animals per sex per dose:
- 5/sex/exposure
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily observation and weekly body weights
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and gross pathology - Statistics:
- Means and standard deviations of animal body weights were calculated for descriptive purposes.
Results and discussion
- Preliminary study:
- none
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 131.58 ppm
- Exp. duration:
- 6 h
- Remarks on result:
- other: substantially saturated vapor concentration (calculated)
- Mortality:
- A single static inhalation exposure to substantially saturated vapor produced no deaths.
- Clinical signs:
- other: A single static inhalation exposure to substantially saturated vapor produced no signs of inhalation toxicity.
- Body weight:
- Body weight gains were observed in rats at 7 and 14 days post -exposure.
- Gross pathology:
- No gross pathologic lesions were found in any of the animals.
- Other findings:
- None
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- A single static inhalation exposure to substantially saturated vapor (equivalent to 131.58 ppm - calculated) produced no deaths or other signs of inhalation toxicity.
- Executive summary:
Ethylene glycol mono hexyl ether was evaluated for acute inhalation test in rats. Sprague-Dawley albino rats, weighing between 200 and 300 g, were exposed to substantially saturated vapor for 6 hours. The vapor was produced by enclosing the test material in a sealed 120-liter animal chamber for approximately 18 hours (static conditions) or by passing air (at 2.5 liters/min) through the sample and then through a 9-liter animal chamber (dynamic conditions). Oxygen was added, as needed, for static exposures to maintain chamber oxygen content of approximately 20%. If deaths occur, exposure times are varied to determine an LT50. Five males and 5 females are included for each exposure period.
Exposure to a statically-generated, substantially saturated vapor produced no deaths of 5 male or 5 female rats during or following the 6-hour test. There were no signs of toxicity or remarkable gross pathologic lesions observed.
A single static inhalation exposure to substantially saturated vapor (equivalent to 131.58 ppm - calculated) produced no deaths or other signs of inhalation toxicity.
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