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EC number: 422-210-5 | CAS number: 68957-94-8 T3P
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-03 till 1995-7
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 92/69/EWG
- Principles of method if other than guideline:
- The lowest feasible concentration fot the P-NMR analysis is about 0.03 mole/L. Thus the requirements of the guideline to test a concentration less than 0.01 mole/L could not quite be met.
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products:
Aliquots were taken after specific time intervals (2.4, 24, 96, 120 h), cooled, and immediately subjected to pH measurement and NMR analysis. - Buffers:
- - pH: 4
- Type and final molarity of buffer: citric acid / sodium hydroxide solution; c = 1 mole/L
- pH: 7
- Type and final molarity of buffer: potassium dihydrogenphosphate / sodium hydroxide solution; c = 1 mole/L
- pH: 9
- Type and final molarity of buffer: glycine / sodium hydroxide solution; c = 2 mole/L
The buffers were prepared in D2O - Details on test conditions:
- TEST SYSTEM
- Type of test flasks: glass flasks - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Number of replicates:
- nor specified
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- Due to peak superposition in the 31P-NMR spectra of the hydrolysis batches, an accurate quantification of the test substance (six-membered ring, cyclic trimer) is not possible. Nevertheless its 31P-NMR spectrum in organic solvents is well known and thus one can estimate that even at t = 0 only a low amount (<15 %) of a six-membered ring is present. The hydrolysis finally results in propane phosphonic acid. During the hydrolysis process a linear trimer and a dimer are generated, which can be identified by NMR spectroscopy. The identification of other intermediates was impossible.
Due to the results of the pre-test the test substance hydrolysis in 24 h at 50 °C and pH 4, 7 and 9 to more than 50 %. The half-life time at 25 °C could therefore be estimated to be < 1 day. According to the mentioned directive no further experimental test are necessary. - Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- No.:
- #3
- % Recovery:
- > 11 - < 13
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 1
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- > 9 - < 14
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 1
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- < 1
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- < 1
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- < 1 d
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- < 1 d
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- < 1 d
- Details on results:
- TEST CONDITIONS
- pH and temperature maintained throughout the study: Yes - Validity criteria fulfilled:
- yes
- Conclusions:
- Due to the results of this pre-test according to EU method C.7 (92/69/EWB), the test substance hydrolysis in 24 h at 50 °C and pH 4, 7 and 9 to more than 50 %. The half-life time at 25 °C could therefore be estimated to be < 1 day. According to the mentioned directive no further experimental test are necessary.
- Executive summary:
In a hydrolysis pre-test according to EU method C.7 (92/69/EWB), the test item hydrolysis in 24h at 50°C and pH 4, 7 and 9 to more than 50%. In detail, the recovery of the test substance at pH 4 after 24 hours at 50°C was between 11 and 13 %, after 120 hours 1%. The recovery of the test substance at pH 7 after 24 hours at 50°C was between 9 and 14 %, after 120 hours 1%. And the recovery of the test substance at pH 9 after 24 and 120 hours at 50°C was below 1%. The half-life time at 25 °C could therefore be estimated to be < 1 day. Therefore, the substance will hydrolyses fast in contact with water under environmental conditions. Hydrolysis will contribute significantly to the degradation of the test item under environmental conditions. According to the mentioned directive no further experimental test are necessary.
Reference
Description of key information
The results of a pre-test according to EU method C.7 (92/69/EWB) show, that the test substance hydrolysis in 24 h at 50 °C and pH 4, 7 and 9 to more than 50 %. The half-life time at 25 °C could therefore be estimated to be < 1 day. According to the mentioned directive no further experimental test are necessary.
Key value for chemical safety assessment
Additional information
In a hydrolysis pre-test according to EU method C.7 (92/69/EWB), the test item hydrolysis in 24h at 50°C and pH 4, 7 and 9 to more than 50%. In detail, the recovery of the test substance at pH 4 after 24 hours at 50°C was between 11 and 13 %, after 120 hours 1%. The recovery of the test substance at pH 7 after 24 hours at 50°C was between 9 and 14 %, after 120 hours 1%. And the recovery of the test substance at pH 9 after 24 and 120 hours at 50°C was below 1%. The half-life time at 25 °C could therefore be estimated to be < 1 day. Therefore, the substance will hydrolyses fast in contact with water under environmental conditions. Hydrolysis will contribute significantly to the degradation of the test item under environmental conditions. According to the mentioned directive no further experimental test are necessary.
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