Registration Dossier
Registration Dossier
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EC number: 226-942-4 | CAS number: 5570-77-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authorized database
Data source
Reference
- Reference Type:
- other: Authorized database
- Title:
- Acute inhalation toxicity of CAS no 109-01-3
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A Toxnet Database, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute inhalation toxicity study 1-Methylpiperazine in mice
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1-Methylpiperazine
- Cas Number:
- 109-01-3
- Molecular formula:
- C5H12N2
- IUPAC Name:
- 1-Methylpiperazine
- Test material form:
- liquid
- Details on test material:
- - Name of test material :1-Methylpiperazine
- Molecular formula :C5H12N2
- Molecular weight:100.1638 g/mole
- Substance type:Organic
- Smiles notation: N1(CCNCC1)C
- InChl: 1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1-Methylpiperazine
- Molecular formula (if other than submission substance): C5H12N2
- Molecular weight (if other than submission substance): 100.1638 g/mole
- Substance type: Organic
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 2 h
- Remarks on duration:
- not specified
- Concentrations:
- 2740 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 2 740 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 2 h
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality observed in exposed mice
- Clinical signs:
- other: Behavioral Excitement, Dyspnea Lungs, Thorax or Respiration and Muscle Contraction or Spasticity were observed in exposed mice.
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LC50 was considered to be 2740 mg/m3 when mice were inhaled with 1-Methylpiperazine.
- Executive summary:
In a acute inhalation toxicity study, mice were inhaled with 2-Chlorobutane in the concentration of 2740mg/m3. 50 % mortality observed in 2740 mg/m3and Behavioral Excitement, Dyspnea Lungs, Thorax or Respiration and Muscle Contraction or Spasticity were observed in exposed mice. Therefore,LC50 was considered to be 2740 mg/m3 when mice were inhaled with1-Methylpiperazine.
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