Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-065-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Skin and eye irritation studies with magnesium silicate were available for evaluation. None of the results indicated any irritant effects of synthetic amorphous magnesium silicate administration. The silicon dioxide results were reported to show the similarity in effect in terms of irritation to the skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Synthetic amorphous magnesium silicate, with molar ratio (SiO2:MgO) range of 1.4-4
Transient slight dermal and ocular reactions were observed following 4 hour semi-occluded application to intact rabbit skin or instillation of the weight equivalent of a volume of 0.1 mL into rabbit eyes. The reactions rapidly resolved and in no case were classification thresholds breached.
In a separate study with synthetic amorphous magnesium silicate, with molar ratio (SiO2:MgO) range of 1.4-4 (known as Magnesol), no erythema or oedema were observed in any rabbit throughout the study.
Silicon dioxide:
In four studies, silicon dioxide applied to intact or abraded skin sites elicited no more than transient slight erythema which had resolved in all case within 72 hours.
In six studies where silicon dioxide was instilled into rabbit eyes as a known weight of powder, other than isolated incidences of slight transient ocular irritation, there were no reactions that indicated an ocular irritant effect.
None of the available data for magnesium silicate or read-across analogues, such as silicon dioxide, gave any indications of irritation/corrosion. The toxicity profile and physico-chemical properties for silicon dioxide and magnesium silicate are similar and warrant read-across for endpoints without additional experimental data on magnesium silicate.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Skin Irritation/Corrosion:
Magnesium silicate was not classified as a skin irritant as it did not fulfil the criteria detailed in Regulation EC No. 1272/2008
Eye Irritation/Corrosion:
Magnesium silicate was not classified as an eye irritant as it did not fulfil the criteria detailed in Regulation EC No. 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
