Registration Dossier
Registration Dossier
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EC number: 629-716-7 | CAS number: 1211950-04-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The safety assessment according to Annex 1 does not indicate the need to investigate further the effects on aquatic organisms. Therefore no chronic fish testing is at this moment considered to be required.
Key value for chemical safety assessment
Additional information
The safety assessment according to Annex 1 does not indicate the need to investigate further the effects on aquatic organisms. Therefore no chronic fish testing is at this moment considered to be required. In addition, fish are in general less sensitive to cationic surfactants as observed for linear alkyl diamines or quats compared to algae and daphnia. The available acute fish data for diquat C16 -18 with an LC50 of 0.35 mg/L
For the calculation of the PNECaquatic bulk it is considered unlikely that fish toxicity will be critical for the branched triamines. Hence any additional toxicity testing with fish will not add scientific value to the ecotoxicity profile of the branched triamines other than for obtaining a lower assessment factor. It is therefore concluded that for scientific reasons and in accordance to REACH legislation further testing on fish has to be avoided for reasons of animal welfare and that based on the weight of evidence available on ecotoxicity data for several cationic surfactants a safety factor of 10 may be applied for the derivation of the PNECaquatic,bulk. The use of this factor of 10 is supported by, the low acute to chronic ratio observed in the long-term daphnia test.
The daphnia reproduction test result shows that at 810 μg/L all parental daphnids were immobile within two days, without reproduction, while at the next concentration of 270 µg/L there is no detrimental effect on reproduction when compared to the control for the surviving daphnia's. These observations result in the derivation of a NOEC of 270 µg/L reproduction resulting in a low acute-to-chronic ratio. A low acute-to-chronic ratio is indicative of a non-specific mode of action and is often associated with not systemic effects. This observation is consistent with the known effects of cationic surfactants on aquatic organisms, where toxicity is associated with physical binding to respiratory membranes. This explains the steep concentration curves seen and the lack of intermediate chronic effects on reproduction.
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