N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide

Guidance on Safe Use

First-aid measures

Eye contact

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.

Skin contact

If ON SKIN: Wash with plenty of soap and water. If skin irritation occurs, get medical advice/attention.

Inhalation

Move to fresh air. Oxygen or artificial respiration if needed. If exposed or concerned: Get medical attention/advice.

Ingestion

IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Never give anything by mouth to an unconscious person.

Notes to Physician

Medical conditions aggravated include: liver disorders, vascular disorders, bleeding, oedema. This product has been reported to interact with the following medications: drugs that inhibit cytochrome P-450, cardiovascular drugs, anticoagulants. Material not fully tested.

Medical Surveillance

The need for a pre-placement, follow-up physical examination and history for employees with potential exposure to this compound is to be evaluated by a physician that is thoroughly knowledgeable about both the toxicity of this compound and the extent of work place exposure. Baseline testing would include: a complete blood count with differential, a blood test for liver function. Based on opportunity for exposure and duration of exposure a periodic follow-up examination may be considered. This exam should be overseen by a physician thoroughly knowledgeable about both the toxicity of this compound and the extent of work place exposure. It is recommended that the content be similar to the pre-placement exam.

Employees who are pregnant, are breast-feeding, or who are concerned with other reproductive issues should be encouraged to consult with the occupational health physician monitoring worker's health.

Fire-fighting measures

Flammable Properties

Flammable solid

Extinguishing Media

Suitable extinguishing media: Dry chemical, Water spray, Foam

Unsuitable extinguishing media: Do NOT use water jet.

Protection of Firefighters

Specific hazards: Not available

Protective equipment: Use personal protective equipment. In the event of fire, wear self-contained breathing apparatus.

Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx), sulphur compounds

Other information

Decontaminate protective clothing and equipment before reuse.

Accidental release measures

Personal precautions

Use personal protective equipment. Examples include tightly fitting safety goggles, disposable lab coat of low permeability with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the nature of the spill (quantity and extent of spill) additional protective clothing and equipment such as a self-contained breathing apparatus may be needed.

Environmental precautions

Prevent release to drains and waterways. Prevent release to the environment.

Containment Methods

Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable material.

Cleanup Methods

Spill prevention procedures and a spill response procedure should be implemented. Contain and collect spillage and place in container for disposal according to local regulations. Clean spill area with a deactivating solution (if available) followed by detergent and water after spill pick-up. Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar materials.

Handling and storage

Handling Precautions

Highly potent material. Avoid exposure - obtain special instructions before use. Avoid formation of dust and aerosols. Keep away from heat and sources of ignition. Prevent release to drains and waterways.

Container Requirements

Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.

Storage Conditions

Store at room temperature. Protect against light. Keep away from heat, sparks and flames. Store locked up.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN2926

Shipping

Labels:

4.1, 6.1

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN2926

Shipping information

Proper shipping name and description:

FLAMMABLE SOLID, TOXIC, ORGANIC, N.O.S. (n-butanol derivative)

Labels:

4.1, 6.1

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN2926

Shipping information

Proper shipping name and description:

FLAMMABLE SOLID, TOXIC, ORGANIC, N.O.S. (n-butanol derivative)

Labels:

4.1, 6.1

Remarks

SpecialProvisions

Exposure controls / personal protection

Recommended Industrial Hygiene Monitoring Methods

A specific exposure sampling method is not available. Contact the Bristol-Myers Squibb AIHA accredited Industrial Hygiene Laboratory at (USA) 732-227-6338.

General - The health hazard risk of handling this material is dependent on many factors, including physical form, % API in material being handled, duration and frequency of process task, and effectiveness of controls. If it is necessary to handle this compound outside of engineering controls, an exposure risk assessment should be conducted and procedures documented by a qualified EHS professional.

Engineering Controls and Ventilation

Use process enclosures, containment technology, or other engineering controls to keep airborne levels below recommended exposure limit. When handling quantities up to 3 milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood, biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly "dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated laboratory or containment facility using appropriate containment technology. A laminar flow/powder containment booth or appropriate isolation technology should be considered for handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For manufacturing and pilot plant operations, barrier/containment technology and direct coupling (totally enclosed processes that create a barrier between the equipment and the room) with use of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box systems are optional. HEPA filtration of exhaust from dry product handling areas is required.

Respiratory protection

Use and selection of respiratory protection is based upon engineering controls in use and potential for aerosol generation. When engineering controls are not sufficient control exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate (HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters (EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tight-fitting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied air respirator (EN 139) operated in a pressure demand or other positive pressure mode when exposures are 100-1000 times the exposure control guideline.

Eye protection

Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety goggles (EN 166) may be required if splash potential exists or if corrosive materials are present. Note: Choice of eye protection may be influenced by the type of respirator which is selected.

Hand protection

Wear gloves at all times when handling containers, including when unpacking, inspecting or transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374). Double gloving for all manufacturing personnel potentially in direct contact with the compound should be considered. If material is handled in solution, the solvent should also be considered when selecting protective clothing material.

Skin and body protection

Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN 1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable coverall of low permeability (EN 1149-1) and disposable shoe covers.

Hygiene

Wash hands and face before breaks and immediately after handling the product.

Environmental exposure controls

Prevent release to drains and waterways.

Stability and reactivity

Chemical Stability: Stable under normal conditions.

Conditions to avoid: Not available

Materials to avoid: Not available

Hazardous decomposition products: Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx), sulphur compounds.

Hazardous reactions: None known.

Sensitivity to static discharge/Dust exp.: Although material has not been specifically tested, fine dust suspended in air in sufficient concentration and in the presence of an ignition source may pose a potential explosion hazard. Provide appropriate bonding and grounding protection to control static charge. Powder handling equipment such as dust collectors, dryers, and mills may require additional protective measures (e.g. explosion venting, inerting, etc.).

Disposal considerations

Advice On Disposal And Packaging: Disposal should be in accordance with applicable regional, national and local laws and regulations. Local regulations may be more stringent than regional or national requirements. This information presented only applies to the material as supplied.

Other information: Disposal by incineration is recommended.