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EC number: 256-155-1 | CAS number: 43229-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 4 May to 20 May 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- N-benzyl-4-methoxy-α-methylphenethylamine
- EC Number:
- 256-155-1
- EC Name:
- N-benzyl-4-methoxy-α-methylphenethylamine
- Cas Number:
- 43229-65-8
- Molecular formula:
- C17H21NO
- IUPAC Name:
- N-benzyl-1-(4-methoxyphenyl)propan-2-amine
- Details on test material:
- - Name of test material (as cited in study report): TH 1165 II
- Physical state: yellow liquid
- Analytical purity: 98.2 % (area)
- Purity test date:
- Lot/batch No.: 61
- Expiration date of the lot/batch: 8 april 2000 (allocated by NOTOX, 1 year after receipt of the test substance)
- Storage condition of test material: at room temperature in the dark
- Stability under storage conditions: not indicated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland G,mbH, Sulzfeld, Germany
- Age at study initiation: approx. 6 weeks
- Weight at study initiation: body weight did not exceed 20% of the sex mean
- Housing: polycarbonate cages, 3 animals per cage
- Fasting period before study: food was withheld overnight (for a maximum of 20 hours) prior to dosing until approximately 3-4 hours after administration of the test substance
- Diet (e.g. ad libitum): Carfil Quality BVBA, Oud-Turnhout, Belgium ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 5 days before start of the treatment
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C
- Humidity (%): 50%
- Photoperiod (hrs dark / hrs light): 12 hrs each
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Initially, TH 1165 II was administered by oral gavage to 3 females Wistar rats at 2000 mg/kg bw. In a stepwise procedure additional groups of animals were dosed at 200 (females) and 200 (males) mg/kg bw. All animals were subjected to daily observations and weekly determination of body weight. macroscopic examination was performed on the day of death or after terminal sacrifice (day 15)
- Doses:
- one dose per animal at 2000 mg/kg b.w.
one dose per animal at 200 mg/kg b.w. - No. of animals per sex per dose:
- 3 female at 2000 mg/kg b. w.
3 female and 3 male at 200 mg/kg bw - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1 day (pre-administration); 8 and 15 and at death (if found dead after day 1).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The incidence of mortality was as follow, presented in chronological order of treatment:
Dose level: Mortality: Sex:
2000 mg/kg 3/3 females
200 mg/kg 0/3 females
200 mg/kg 0/3 males - Clinical signs:
- no clinical signs were noted.
- Body weight:
- The body weight gain shown by the surviving animals over the study period was considered to be similar to that expected of normal untreated animals of the same age and strain
- Gross pathology:
- no autopsy findings were noted.
- Other findings:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 value of TH 1165 II in Wistar rats was established 200-2000 mg/kg bw.
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